Fadrozole

Fadrozole_structure.svg

Fadrozole is a nonsteroidal aromatase inhibitor that is primarily used in the treatment of estrogen receptor-positive breast cancer. It works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens to estrogens. This reduction in estrogen levels can help slow the growth of certain types of breast cancer that require estrogen to grow.

Mechanism of Action

Fadrozole inhibits the aromatase enzyme, which is a key enzyme in the biosynthesis of estrogens. By blocking this enzyme, fadrozole reduces the production of estrogens from androgens in peripheral tissues. This leads to a decrease in circulating estrogen levels, which can help in the management of estrogen-dependent conditions such as breast cancer.

Clinical Uses

Fadrozole is primarily used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. It may also be used in other conditions where estrogen suppression is beneficial, although its use is less common compared to other aromatase inhibitors like anastrozole and letrozole.

Side Effects

Common side effects of fadrozole include:

• Hot flashes
• Nausea
• Fatigue
• Headache
• Joint pain

Less common but more serious side effects can include:

• Osteoporosis
• Cardiovascular events
• Liver dysfunction

Pharmacokinetics

Fadrozole is administered orally and is well-absorbed from the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily in the urine. The half-life of fadrozole allows for once-daily dosing.

Comparison with Other Aromatase Inhibitors

Fadrozole is one of several aromatase inhibitors used in the treatment of breast cancer. Other commonly used aromatase inhibitors include anastrozole, letrozole, and exemestane. Each of these drugs has a slightly different mechanism of action and side effect profile, but all work to reduce estrogen levels in the body.

Research and Development

Research is ongoing to better understand the full potential of fadrozole in various estrogen-dependent conditions. Studies are also being conducted to compare its efficacy and safety profile with other aromatase inhibitors.

See Also

• Aromatase
• Breast cancer
• Anastrozole
• Letrozole
• Exemestane

External Links

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