5α-Androstan-3α-ol
Overview
5α-Androstan-3α-ol is a steroid metabolite that plays a significant role in the metabolism of androgens and neurosteroids. It is a derivative of dihydrotestosterone (DHT), which is a potent androgen hormone. This compound is part of the androstanes group, characterized by a saturated carbon ring structure.
Chemical Structure
5α-Androstan-3α-ol is a saturated steroid with the chemical formula C19H32O. It features a hydroxyl group (-OH) at the 3α position on the steroid backbone, which is crucial for its biological activity. The compound is a stereoisomer of 5α-Androstan-3β-ol, differing only in the orientation of the hydroxyl group.
Biosynthesis
5α-Androstan-3α-ol is synthesized from dihydrotestosterone through the action of the enzyme 3α-hydroxysteroid dehydrogenase (3α-HSD). This enzyme catalyzes the reduction of the 3-keto group in DHT to a hydroxyl group, resulting in the formation of 5α-Androstan-3α-ol.
Biological Function
5α-Androstan-3α-ol is involved in the modulation of androgen receptor activity. Although it is less potent than DHT, it can still bind to androgen receptors and influence gene expression. Additionally, it is considered a neurosteroid, meaning it can modulate neurotransmitter systems in the brain, potentially affecting mood and behavior.
Clinical Significance
The levels of 5α-Androstan-3α-ol can be indicative of certain medical conditions. Abnormal levels may be associated with disorders of androgen metabolism, such as androgen insensitivity syndrome or 5α-reductase deficiency. Understanding its role in these conditions can aid in diagnosis and treatment.
Research and Applications
Research into 5α-Androstan-3α-ol is ongoing, particularly in the fields of endocrinology and neuroscience. Its role as a neurosteroid is of particular interest, as it may have implications for the treatment of depression, anxiety, and other neuropsychiatric disorders.
Also see
- Dihydrotestosterone
- 3α-Hydroxysteroid dehydrogenase
- Androgen receptor
- Neurosteroid
- Androgen insensitivity syndrome
| Androgens and antiandrogens | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
