Propylhexedrine
(Redirected from Levopropylhexedrine)
What is Propylhexedrine?
- Propylhexedrine (Benzedrex) is a nasal decongestant, appetite suppressant, and psychostimulant medication. It is used medicinally for relief of congestion due to colds, allergies and allergic rhinitis.
What are the uses of this medicine?
- Propylhexedrine (Benzedrex) used for the temporarily relief of nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis).
How does this medicine work?
- Propylhexedrine is a TAAR1 agonist, like amphetamine.
- Consequently, it reverses the transporters for dopamine, norepinephrine, and serotonin, leading to a release of monoamines from presynaptic vesicles into the synaptic cleft.
- The increased level of monoamines within the synapse results in increased activity at their respective receptors.
- Additionally, propylhexedrine appears to inhibit VMAT2, leading to a further increase in the aforementioned monoamines.
- The pharmacological actions of propylhexedrine are similar to that of structurally similar stimulant phenethylamines, such as amphetamine.
Who Should Not Use this medicine ?
This medicine cannot be used with:
- MAOI has been used in the past 14 days or is currently in use.
- stimulant drugs and sympathomimetics
What drug interactions can this medicine cause?
- Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
Be sure to mention any of the following:
Is this medicine FDA approved?
- Propylhexedrine is most commonly found in over-the-counter Benzedrex inhalers. Benzedrex was first manufactured by Smith, Kline and French after the Benzedrine inhaler, which contained racemic amphetamine, became unavailable following the placement of amphetamines on the US Schedule II status (highest abuse potential, yet with accepted medicinal uses).
- Benzedrex is currently manufactured by B.F. Ascher & Co. Inc. Pharmaceuticals.
- On the 4th of April 1988, propylhexedrine was designated a controlled substance (Schedule V) in the United States.
- This was done to satisfy U.S. compliance with an international treaty. However, in 1991 this action was reversed and propylhexedrine was removed from control under the Controlled Substances Act, based on the opinion of the Drug Enforcement Administration that propylhexedrine did not warrant control.
How should this medicine be used?
Recommended dosage and Administration:
- adults and children 6 to 12 years of age (with adult supervision): two inhalations in each nostril not more than every two hours.
- children under 6 years of age: consult a doctor
What are the dosage forms and brand names of this medicine?
This medicine is available in fallowing doasage form:
- As propylhexedrine inhalant
This medicine is available in fallowing brand namesː
- Benzedrex
What side effects can this medication cause?
The most common side effects of this medicine include:
- sweating, talkativeness, mydriasis, emotional lability, anorexia, tachycardia, palpitations, dry mouth, bruxism, anxiety, euphoria or dysphoria, increased aggressiveness, paranoia, headache, dizziness, psychosis, slurred or impaired speech, rarely convulsions and serious heart problems.
- Propylhexedrine can also cause swelling, dryness and irritation of mucous membranes.
What special precautions should I follow?
- Do not exceed recommended dosage.
- This product may cause temporary discomfort such as burning, stinging, sneezing, or an increase in nasal discharge.
- The use of this container by more than one person may spread infection.
- Use only as directed.
- Frequent or prolonged use may cause nasal congestion to recur or worsen.
- Ill effects may result if taken internally
- Do not use this product for more than three days.
- Stop use and consult a doctor if symptoms persist.
What to do in case of emergency/overdose?
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?
- If pregnant or breast-feeding, ask a health professional before use.
Can this medicine be used in children?
- children under 6 years of age: consult a doctor
What are the active and inactive ingredients in this medicine?
Active ingredient:
- PROPYLHEXEDRINE
Inactive ingredients:
- LAVENDER OIL
- MENTHOL
Who manufactures and distributes this medicine?
- mfd. in USA for B.F. Ascher & Co., Inc.
What should I know about storage and disposal of this medication?
- Store at 59°-86° F (15°-30° C).
- Keep inhaler tightly closed.
- This inhaler is effective for a minimum of 3 months after first use.
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