LY-307,452

LY-307,452

LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR_2/3),<ref name="pmid8632404">Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD,

 (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase, 
 Journal of Medicinal Chemistry, 
 
 Vol. 39(Issue: 4),
 pp. 814–6,
 DOI: 10.1021/jm9508144,
 PMID: 8632404,</ref> and was useful in early studies of this receptor family,<ref name="pmid10516668">Li XC, Beart PM, Monn JA, Jones NM, Widdop RE, 
 Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats, 
 British Journal of Pharmacology, 
 
 Vol. 128(Issue: 3),
 pp. 823–9,
 DOI: 10.1038/sj.bjp.0702850,
 PMID: 10516668,
 PMC: 1571690,</ref><ref name="pmid11698530">Sung KW, Choi S, Lovinger DM, 
 Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses, 
 Journal of Neurophysiology, 
 
 Vol. 86(Issue: 5),
 pp. 2405–12,
 
 PMID: 11698530,</ref> although it has largely been replaced by newer drugs such as LY-341,495.

References

<references/>

Glutamate receptor modulators

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