5-Iodowillardiine

5-Iodowillardiine

Chemical structure of 5-Iodowillardiine

5-Iodowillardiine is a chemical compound that acts as an agonist at certain subtypes of the ionotropic glutamate receptor, specifically the AMPA receptor and the kainate receptor. It is a derivative of the naturally occurring compound willardiine, with an iodine atom substituted at the 5-position of the uracil ring.

Chemical Properties

5-Iodowillardiine is a synthetic analog of willardiine, characterized by the presence of an iodine atom. This modification enhances its ability to selectively activate certain glutamate receptors. The compound's molecular formula is C_H_IN_O_, and it has a molar mass of 298.03 g/mol.

Mechanism of Action

5-Iodowillardiine functions as an agonist at the AMPA and kainate subtypes of ionotropic glutamate receptors. These receptors are ligand-gated ion channels that mediate fast synaptic transmission in the central nervous system. Upon binding to these receptors, 5-Iodowillardiine induces a conformational change that opens the ion channel, allowing the influx of cations such as Na_ and Ca__, leading to neuronal depolarization and excitatory neurotransmission.

Applications in Research

Due to its selective agonistic properties, 5-Iodowillardiine is used in neuroscience research to study the function and pharmacology of AMPA and kainate receptors. It helps in elucidating the role of these receptors in synaptic plasticity, learning, and memory. Additionally, it is used to investigate the pathophysiology of neurological disorders such as epilepsy and neurodegenerative diseases.

Safety and Handling

As with many research chemicals, appropriate safety precautions should be taken when handling 5-Iodowillardiine. It should be used in a controlled laboratory environment, with personal protective equipment such as gloves and goggles. The compound should be stored in a cool, dry place, away from light and moisture.

Related Pages

• Glutamate receptor
• AMPA receptor
• Kainate receptor
• Willardiine