NS102

NS102 is a chemical compound that is used in neuroscience research. It is a selective, non-competitive antagonist at the kainate receptor, a type of ionotropic glutamate receptor. NS102 has been used in various studies to investigate the role of kainate receptors in the central nervous system.

Chemistry

NS102 is a quinazolinone derivative. It has a molecular weight of 366.4 g/mol and a chemical formula of C20H17N3O3. The compound is usually supplied as a hydrochloride salt.

Pharmacology

NS102 is a selective antagonist at the kainate receptor, meaning it binds to this receptor and prevents it from being activated by its natural ligand, glutamate. It does this in a non-competitive manner, meaning it does not compete with glutamate for the same binding site on the receptor. Instead, it binds to a separate site and changes the receptor's conformation so that glutamate cannot activate it.

Use in Research

NS102 has been used in various studies to investigate the role of kainate receptors in the central nervous system. For example, it has been used to study the receptors' role in synaptic plasticity, a process that is crucial for learning and memory. It has also been used to investigate the receptors' involvement in neurological disorders such as epilepsy and Parkinson's disease.

See Also

• Kainate receptor
• Glutamate receptor
• Neuroscience
• Neurological disorders

References

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