Alaproclate
A selective serotonin reuptake inhibitor
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Alaproclate is a pharmacological compound that functions as a selective serotonin reuptake inhibitor (SSRI). It was primarily researched for its potential use as an antidepressant but is not currently marketed for clinical use.
Mechanism of Action
Alaproclate acts by inhibiting the reuptake of serotonin (5-HT) into the presynaptic neuron, thereby increasing the availability of serotonin in the synaptic cleft. This mechanism is similar to that of other SSRIs, which are commonly used in the treatment of depression and anxiety disorders.
Pharmacokinetics
The pharmacokinetic profile of alaproclate includes its absorption, distribution, metabolism, and excretion. Alaproclate is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily through the kidneys.
Synthesis
The synthesis of alaproclate involves several chemical reactions, starting from basic organic compounds. The process is depicted in the image below:
Clinical Research
Alaproclate was studied in clinical trials to evaluate its efficacy and safety as an antidepressant. However, it did not progress to become a marketed drug. The reasons for this could include insufficient efficacy, adverse effects, or the development of more effective alternatives.
Side Effects
As with other SSRIs, alaproclate may cause side effects such as nausea, headache, dizziness, and insomnia. The side effect profile is an important consideration in the development and approval of new pharmacological agents.
Related Compounds
Alaproclate is related to other SSRIs such as fluoxetine, sertraline, and citalopram. These compounds share a similar mechanism of action but may differ in their pharmacokinetic properties and side effect profiles.
Related pages
Gallery
Structure of Alaproclate
Structure of Alaproclate
Synthesis of Alaproclate
Alaproclate
Chemical structure of Alaproclate
Synthesis pathway of Alaproclate
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Contributors: Prab R. Tumpati, MD
