CXCR5

CXCR5 is a G protein-coupled receptor that in humans is encoded by the CXCR5 gene. It is also known as Burkitt lymphoma receptor 1 (BLR1), and is a member of the CXC chemokine receptor family.

Function

CXCR5 is a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and T cells, and is known to control the migration of these cells in lymphoid tissues. The receptor is activated by a chemokine known as CXCL13 (also known as BLC or BCA-1), which is produced in the lymphoid follicles of the spleen, lymph nodes, and Peyer's patches.

Clinical significance

Alterations in the CXCR5 gene have been associated with various diseases. For instance, mutations in this gene have been linked to Burkitt's lymphoma, a type of non-Hodgkin lymphoma. Additionally, the CXCR5-CXCL13 axis is thought to play a role in the pathogenesis of autoimmune diseases such as Multiple sclerosis and Rheumatoid arthritis.

See also

• Chemokine receptor
• Chemokine
• CXCL13
• Burkitt's lymphoma

References

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External links

• CXCR5 at the US National Library of Medicine Medical Subject Headings (MeSH)

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