CEACAM8

CEACAM8 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8) is a protein that in humans is encoded by the CEACAM8 gene. It is a member of the carcinoembryonic antigen (CEA) gene family.

Function

CEACAM8 is a cell adhesion molecule and a member of the immunoglobulin superfamily. It is expressed on the surface of granulocytes and plays a role in inflammation and immune response. It is also involved in the process of cell adhesion and in the activation of granulocytes.

Clinical significance

Alterations in the expression of CEACAM8 have been associated with various diseases, including cancer, inflammatory diseases, and infectious diseases. It has been suggested as a potential biomarker for these conditions.

Structure

The CEACAM8 protein is a type I transmembrane protein that consists of an extracellular region, a single transmembrane region, and a short cytoplasmic tail. The extracellular region contains three immunoglobulin-like domains.

Interactions

CEACAM8 has been shown to interact with other members of the CEA family, including CEACAM1, CEACAM3, and CEACAM6.

See also

• Carcinoembryonic antigen
• Cell adhesion molecule
• Granulocyte
• Inflammation
• Immune response