GP5 (gene)
GP5 (gene)
GP5 is a gene that encodes the glycoprotein V (platelet) protein in humans. This protein is a component of the platelet glycoprotein complex, which plays a crucial role in the blood coagulation process.
Function
The GP5 gene is part of the glycoprotein Ib-IX-V complex, which is essential for normal hemostasis. This complex is involved in the initial adhesion of platelets to the vascular subendothelium after vascular injury. The GP5 protein, along with other components of the complex, binds to von Willebrand factor (vWF), facilitating platelet adhesion and aggregation at sites of vascular damage.
Clinical Significance
Mutations or defects in the GP5 gene can lead to bleeding disorders due to impaired platelet function. The GP5 protein is also a target for certain antiplatelet drugs used in the treatment of thrombotic disorders.
Research
Studies on the GP5 gene and its protein product are ongoing to better understand their roles in thrombosis and hemostasis. Research is also focused on developing new therapeutic strategies targeting the GP5 protein to prevent or treat cardiovascular diseases.
See Also
References
External Links
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Contributors: Prab R. Tumpati, MD
