CD6
CD6
CD6 (pronounced "C-D-six"), also known as Cluster of Differentiation 6, is a protein that in humans is encoded by the CD6 gene. It is a member of the scavenger receptor cysteine-rich (SRCR) superfamily and primarily functions as a co-stimulatory molecule during T cell activation.
Etymology
The term "CD6" is derived from the phrase "Cluster of Differentiation 6". The "Cluster of Differentiation" terminology was established in the 1980s during a series of international workshops intended to define markers on the surface of leukocytes (white blood cells). The number "6" was assigned to this particular protein because it was the sixth differentiation cluster identified.
Function
CD6 is a cell surface glycoprotein that is expressed on mature T cells and a subset of B cells. It plays a crucial role in the adaptive immune response, primarily functioning as a co-stimulatory molecule during T cell activation. CD6 interacts with its ligand, CD166 (also known as ALCAM), to mediate cell adhesion and signal transduction.
Related Terms
- T cell: A type of white blood cell that is of key importance to the immune system and is at the core of adaptive immunity.
- B cell: A type of white blood cell of the lymphocyte subtype, they function in the humoral immunity component of the adaptive immune system by secreting antibodies.
- ALCAM: Activated leukocyte cell adhesion molecule, also known as CD166, is a protein that in humans is encoded by the ALCAM gene.
- Leukocytes: White blood cells, which are cells of the immune system involved in protecting the body against both infectious disease and foreign invaders.
External links
- Medical encyclopedia article on CD6
- Wikipedia's article - CD6
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