CCR2

CCR2 is a protein that in humans is encoded by the CCR2 gene. It is also known as CD192 (cluster of differentiation 192), which is a receptor for monocyte chemoattractant protein-1 (MCP-1), a chemokine which specifically mediates monocyte chemotaxis.

Function

CCR2 is a member of the chemokine receptor family, and its function is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system. The chemokine receptor is involved in the regulation of monocyte infiltration into inflammatory sites. Moreover, it plays a crucial role in the pathogenesis of several chronic inflammatory diseases such as rheumatoid arthritis, atherosclerosis and lupus.

Clinical significance

Mutations in the CCR2 gene have been associated with an increased risk of HIV disease progression. In addition, the encoded protein is a functional receptor for the human herpesvirus 6 (HHV-6), and drugs that block this receptor could potentially be used in the treatment of HHV-6 infection.

See also

• Chemokine receptor
• Monocyte
• Chemokine
• HIV
• Herpesvirus

External links

• WikiMD: CCR2