CCR2
CCR2 is a protein that in humans is encoded by the CCR2 gene. It is also known as CD192 (cluster of differentiation 192), which is a receptor for monocyte chemoattractant protein-1 (MCP-1), a chemokine which specifically mediates monocyte chemotaxis.
Function[edit]
CCR2 is a member of the chemokine receptor family, and its function is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system. The chemokine receptor is involved in the regulation of monocyte infiltration into inflammatory sites. Moreover, it plays a crucial role in the pathogenesis of several chronic inflammatory diseases such as rheumatoid arthritis, atherosclerosis and lupus.
Clinical significance[edit]
Mutations in the CCR2 gene have been associated with an increased risk of HIV disease progression. In addition, the encoded protein is a functional receptor for the human herpesvirus 6 (HHV-6), and drugs that block this receptor could potentially be used in the treatment of HHV-6 infection.
See also[edit]
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