CD23

CD23, also known as the low affinity immunoglobulin epsilon Fc receptor, is a protein that in humans is encoded by the FCER2 gene. CD23 is found on the surface of B cells, a type of white blood cell. It plays a role in the immune system's response to allergens.

Function

CD23 is involved in the regulation of IgE antibody levels. It also participates in the immune response against parasites. CD23 can be cleaved from the surface of B cells, and the soluble form of CD23 (sCD23) can stimulate the release of pro-inflammatory cytokines and increase the production of IgE.

Clinical significance

Alterations in the CD23 protein have been associated with a variety of diseases. For example, increased levels of sCD23 are found in the blood of people with chronic lymphocytic leukemia and HIV infection. In addition, mutations in the FCER2 gene that encodes CD23 have been linked to a higher risk of developing asthma and other allergic diseases.

Research

CD23 is being studied as a potential target for the treatment of various diseases, including asthma, chronic lymphocytic leukemia, and HIV infection. Several drugs that target CD23 are currently in clinical trials.

See also

• FCER2
• IgE
• B cell
• Chronic lymphocytic leukemia
• HIV
• Asthma
• Allergic diseases

References

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CD23

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