CD23
CD23
CD23, also known as Fc epsilon RII, or FcεRII (pronounced as "C-D-Twenty-Three"), is a type of protein that in humans is encoded by the FCER2 gene. It is a member of the immunoglobulin superfamily and is known to play a key role in the immune system.
Etymology
The term "CD23" stands for "Cluster of Differentiation 23". The "CD" nomenclature was established at a series of international workshops intended to classify monoclonal antibodies against leukocyte surface antigens.
Function
CD23 is primarily found on mature B cells, activated macrophages, eosinophils, and follicular dendritic cells. It is involved in IgE antibody regulation and allergic responses. CD23 also plays a role in several immune system functions, including B-cell proliferation and differentiation, IgE production, and regulation of IgG and IgM production.
Related Terms
- B cells: A type of white blood cell that produces antibodies.
- Macrophages: A type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, and cancer cells.
- Eosinophils: A type of disease-fighting white blood cell.
- Follicular dendritic cells: Cells that capture antigens and present them to B cells in the lymph nodes.
- IgE: A class of antibodies that are primarily responsible for allergic reactions.
- IgG: The most common type of antibody found in blood circulation.
- IgM: The first antibody to be made by the body to fight a new infection.
External links
- Medical encyclopedia article on CD23
- Wikipedia's article - CD23
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