Poliovirus receptor-related 2

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (cluster of differentiation 112), is a human gene that encodes for the PVRL2 protein. This protein is a member of the nectin family and is involved in various cellular processes, including cell adhesion and the formation of cell junctions.

Structure

The PVRL2 gene is located on the short (p) arm of chromosome 19 at position 13.2. The protein encoded by this gene has a molecular weight of approximately 58 kDa and is composed of 467 amino acids. It contains three immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tail.

Function

PVRL2 is a cell adhesion molecule that interacts with other nectin family members to form cell-cell junctions. It is involved in the formation of adherens junctions and tight junctions, which are critical for maintaining the integrity of epithelial tissues. PVRL2 also serves as a receptor for certain viruses, including poliovirus and herpes simplex virus.

Clinical significance

Mutations in the PVRL2 gene have been associated with a variety of diseases. For example, alterations in this gene have been implicated in cleft lip and cleft palate, conditions that affect the structure of the mouth. Additionally, PVRL2 has been identified as a potential therapeutic target in certain types of cancer, including lung cancer and breast cancer.

See also

• Nectin
• Cell adhesion
• Poliovirus