CD70

CD70 is a protein that in humans is encoded by the CD70 gene. CD70 is a member of the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNF receptor superfamily member 27 (TNFRSF27/CD27). It is a surface antigen on activated B cells and activated T cells, and is induced by interleukin-2 (IL-2).

Function

CD70 is a transmembrane protein that is expressed on activated lymphocytes. It interacts with CD27 to play a crucial role in T cell activation, B cell proliferation and differentiation, cytotoxic T cell induction, and immunoglobulin synthesis.

Clinical significance

CD70 has been implicated in various diseases. It is overexpressed in renal cell carcinoma and is associated with poor prognosis. It is also involved in autoimmune diseases, and blocking CD70-CD27 interactions has been proposed as a therapeutic strategy.

Interactions

CD70 has been shown to interact with CD27.

References

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• et al. (1997). "CD70 is critical for CD28-independent CD8+ T cell proliferation". J. Immunol. 158 (8): 3635–3637. PMID 9103409.
• et al. (1997). "CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses". J. Immunol. 158 (9): 4026–4034. PMID 9126981.

External links

• CD70 at the US National Library of Medicine Medical Subject Headings (MeSH)