CD137
CD137
CD137 (pronounced "C-D-one-thirty-seven"), also known as 4-1BB, is a protein that in humans is encoded by the TNFRSF9 gene. It is a member of the tumor necrosis factor (TNF) receptor superfamily.
Pronunciation
CD137 is pronounced as "C-D-one-thirty-seven".
Etymology
The term "CD137" is derived from the system of Cluster of Differentiation (CD), which is used to categorize white blood cells, or leukocytes, and cell surface molecules. The number 137 is simply a unique identifier within this system.
Function
CD137 is a costimulatory protein found on several types of immune cells, including T cells and NK cells. It plays a crucial role in the regulation of immune responses, including the activation and proliferation of T cells and the production of cytokines. CD137 is also involved in apoptosis, an important process in the body's defense against cancer.
Related Terms
- Tumor Necrosis Factor (TNF): A group of cytokines that can cause cell death (apoptosis).
- Costimulatory Protein: A type of protein that provides a secondary signal necessary for T cell activation and survival.
- T Cells: A type of white blood cell that is crucial to the immune response.
- NK Cells: A type of lymphocyte that plays a major role in the host-rejection of both tumors and virally infected cells.
- Apoptosis: The process of programmed cell death.
See Also
External links
- Medical encyclopedia article on CD137
- Wikipedia's article - CD137
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