Tissue factor
Tissue Factor
Tissue factor (TF), also known as CD142 or coagulation factor III, is a protein encoded by the F3 gene in humans. It is a cell surface glycoprotein that initiates the extrinsic pathway of blood coagulation in response to tissue damage.
Pronunciation
Tissue factor: /ˈtɪʃuː ˈfæktər/
Etymology
The term "tissue factor" is derived from its role in the coagulation process where it is released from damaged tissues.
Function
Tissue factor is a transmembrane protein that is found on the surface of many cell types including endothelial cells and monocytes. It acts as a receptor and essential cofactor for factor VIIa, one of the proteins that cause blood to clot in the coagulation cascade. The binding of factor VIIa to tissue factor accelerates the conversion of factor X to Xa, leading to the formation of a clot.
Related Terms
- Coagulation: The process by which blood changes from a liquid to a gel, forming a clot.
- Endothelial cells: Cells that line the interior surface of blood vessels and lymphatic vessels.
- Monocytes: A type of white blood cell that can become macrophages and which are part of the human body's immune system.
- Factor VII: One of the proteins that cause blood to clot in the coagulation cascade.
- Factor X: An enzyme, also known as Stuart-Prower factor, that plays a role in blood coagulation.
External links
- Medical encyclopedia article on Tissue factor
- Wikipedia's article - Tissue factor
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