CD24

CD24 is a protein that in humans is encoded by the CD24 gene. It is a cell adhesion molecule.

Structure

CD24 is a heavily N-glycosylated GPI-linked cell surface protein. The protein consists of a small peptide backbone, where the mature protein is attached to the GPI anchor. This anchor is attached to the C-terminus of the protein. The protein also has a short N-terminus on the other side of the anchor.

Function

CD24 is a cell adhesion molecule, which is a molecule that aids in the connection of cells. It is involved in the regulation of T cell activation and proliferation. The protein is also involved in apoptosis, the process of programmed cell death. It is expressed in neural tissues and plays a role in the differentiation and function of the nervous system.

Clinical significance

CD24 has been identified as a marker for cancer stem cells. It is expressed in many types of cancer, including breast cancer, ovarian cancer, non-small cell lung cancer, colorectal cancer, and pancreatic cancer. It is also associated with poor prognosis in these cancers.

See also

• Cluster of differentiation
• Cancer stem cell
• Cell adhesion molecule

References

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