CEACAM1

CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1) is a protein that in humans is encoded by the CEACAM1 gene. It is a member of the carcinoembryonic antigen (CEA) gene family.

Function

CEACAM1 is a cell surface glycoprotein that is anchored into the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. It plays a role in cell adhesion and intracellular signaling, and is involved in various cellular processes such as angiogenesis, apoptosis, and cell proliferation.

Structure

The CEACAM1 protein consists of an extracellular domain, a single transmembrane domain, and a cytoplasmic domain. The extracellular domain contains several immunoglobulin-like domains, which are involved in cell adhesion.

Clinical significance

Alterations in the expression of CEACAM1 have been associated with various types of cancer, including colorectal cancer, breast cancer, and lung cancer. It is also involved in the regulation of insulin action, and alterations in its expression have been associated with type 2 diabetes.

File:Protein CEACAM1 PDB 2gk2.png

Structure of the CEACAM1 protein.

See also

• Carcinoembryonic antigen
• Cell adhesion
• Glycoprotein
• Gene

References

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External links

• GeneCards - CEACAM1