IGLL1
IGLL1 (Immunoglobulin Lambda-Like Polypeptide 1) is a protein that in humans is encoded by the IGLL1 gene. This protein is a member of the immunoglobulin gene superfamily and is located in the chromosome 22 region, which is associated with leukemia.
Function[edit]
The IGLL1 protein is a surrogate light chain that plays a central role in early B cell development. It forms a pre-B cell receptor complex with immunoglobulin heavy chains, which is essential for B cell maturation.
Clinical significance[edit]
Mutations in the IGLL1 gene have been associated with agammaglobulinemia-2, a condition characterized by the lack of mature B cells and antibodies. This condition leads to a high susceptibility to bacterial infections.
See also[edit]
References[edit]
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External links[edit]
- IGLL1 at the National Center for Biotechnology Information
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