ACKR3

ACKR3 (Atypical Chemokine Receptor 3), also known as CXCR7, is a protein that in humans is encoded by the ACKR3 gene. This protein is a member of the G protein-coupled receptor family, and functions as a chemokine receptor.

Function

ACKR3 is a receptor for the chemokine CXCL12/SDF1 and the interleukin IL-3. It is involved in cell migration, cell proliferation, and cell survival. It is also involved in the regulation of immune responses, hematopoiesis, and embryogenesis.

Clinical significance

Alterations in the ACKR3 gene have been associated with various diseases, including cancer, cardiovascular disease, and inflammatory diseases. In cancer, ACKR3 has been implicated in tumor growth, angiogenesis, and metastasis. In cardiovascular disease, it has been associated with atherosclerosis, myocardial infarction, and heart failure. In inflammatory diseases, it has been linked to rheumatoid arthritis, asthma, and inflammatory bowel disease.

Research

Research is ongoing to develop drugs that target ACKR3 for the treatment of these diseases. Several small molecules and antibodies that bind to and inhibit ACKR3 have been identified, and some are in clinical trials.

See also

• Chemokine receptor
• G protein-coupled receptor
• CXCL12/SDF1
• Interleukin

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