Interleukin 12 receptor, beta 1 subunit

From WikiMD's WELLNESSPEDIA

Interleukin 12 receptor, beta 1 subunit (IL12RB1) is a type of protein that in humans is encoded by the IL12RB1 gene. This protein is a subunit of the interleukin 12 (IL-12) receptor complex. The IL-12 receptor is a heterodimeric receptor formed by IL12RB1 and IL12RB2.

Function[edit]

The IL12RB1 protein is expressed on T cells, natural killer cells, and dendritic cells. It is involved in IL-12-mediated signaling pathway and is important for the differentiation of Th1 cells, a type of T helper cell. IL12RB1 is also involved in enhancing the cytotoxic activity of natural killer cells and promoting the production of IFN-gamma by T cells and natural killer cells.

Clinical significance[edit]

Mutations in the IL12RB1 gene can lead to IL12RB1 deficiency, a primary immunodeficiency disorder. This condition is characterized by increased susceptibility to infections caused by mycobacterium, including tuberculosis and BCG vaccine complications. IL12RB1 deficiency is inherited in an autosomal recessive manner.

See also[edit]

References[edit]

Stub icon

This protein-related article is a stub. You can help WikiMD by expanding the page.

Stub icon

This medical article is a stub. You can help WikiMD by expanding the page.


Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.org/index.php?title=Interleukin_12_receptor,_beta_1_subunit&oldid=6510514"