IL18R1

IL18R1 is a gene that encodes the interleukin 18 receptor 1 protein in humans. This receptor is a part of the interleukin-1 receptor family and is primarily involved in immune responses.

Function

The IL18R1 gene is responsible for the production of the interleukin 18 receptor 1 protein. This protein is a part of the interleukin-1 receptor family, which plays a crucial role in mediating the immune response in the body. The receptor is activated by the cytokine interleukin 18 and is involved in the activation of nuclear factor kappa-B.

Clinical Significance

Mutations in the IL18R1 gene have been associated with several immune system disorders, including asthma, rheumatoid arthritis, and inflammatory bowel disease. Studies have also suggested a potential role of IL18R1 in the pathogenesis of autoimmune diseases.

Research

Research into the IL18R1 gene and its associated protein is ongoing, with a focus on understanding its role in immune response and potential implications for the treatment of immune system disorders.

See Also

• Interleukin 18
• Interleukin-1 receptor family
• Nuclear factor kappa-B

References

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