CD38
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4, CD8, B cells and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
Function
CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. This molecule is necessary for the regulation of intracellular calcium.
Clinical significance
CD38 has been used as a prognostic marker in leukemia. It is also a target of the drug Daratumumab, which is used in the treatment of multiple myeloma.
See also
References
External links
- CD38 at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Contributors: Prab R. Tumpati, MD
