CD38
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4, CD8, B cells and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
Function[edit]
CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. This molecule is necessary for the regulation of intracellular calcium.
Clinical significance[edit]
CD38 has been used as a prognostic marker in leukemia. It is also a target of the drug Daratumumab, which is used in the treatment of multiple myeloma.
See also[edit]
References[edit]
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External links[edit]
- CD38 at the US National Library of Medicine Medical Subject Headings (MeSH)
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