CD28

CD28 is a protein that in humans is encoded by the CD28 gene. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. It is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins.

Function

CD28 is the primary co-stimulatory molecule that has a crucial role in the control of T cell responses. The engagement of CD28 by its ligands CD80 and CD86 provides the second signal required for the full activation of naive T cells following TCR (T cell receptor) stimulation.

Clinical significance

CD28 is involved in several diseases including autoimmune diseases and cancer. In autoimmune diseases, the function of CD28 is often dysregulated leading to excessive T cell responses. In cancer, CD28 can be exploited by tumors to evade the immune response.

See also

• Cluster of differentiation
• T cell
• Autoimmune disease
• Cancer

External links

• CD28 at WikiMD