IL17RA

Interleukin-17 receptor A (IL17RA) is a protein that in humans is encoded by the IL17RA gene. This receptor is a part of the interleukin-17 receptor family and plays a crucial role in immune responses.

Function

IL17RA is a type I transmembrane protein that binds to interleukin 17 (IL-17), a cytokine produced by activated T cells. The binding of IL-17 to IL17RA triggers a signaling cascade that leads to the activation of NF-kB and mitogen-activated protein kinase (MAPK) pathways, which are important for the inflammatory response.

Clinical significance

Mutations in the IL17RA gene can lead to immune system disorders, as the receptor is essential for the proper functioning of the immune system. Dysregulation of IL17RA signaling has been implicated in autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis.

Interactions

IL17RA interacts with several other proteins to mediate its effects. It forms a complex with IL17RC to bind IL-17A and IL-17F, which are key cytokines in the inflammatory response. This receptor complex is critical for the downstream signaling that leads to the production of pro-inflammatory cytokines.

See also

• Interleukin-17
• Cytokine receptor
• Autoimmune disease

References

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External links

• IL17RA gene - NCBI
• IL17RA protein - UniProt