CD74
CD74
CD74 (pronounced "C-D-seventy-four"), also known as the HLA class II histocompatibility antigen gamma chain, is a protein that in humans is encoded by the CD74 gene.
Pronunciation
CD74 is pronounced as "C-D-seventy-four".
Etymology
The term CD74 is derived from the system of Cluster of Differentiation, a protocol used for the identification and investigation of cell surface molecules present on leukocytes. CD74 was the 74th distinct cluster of differentiation identified.
Function
CD74 is an integral membrane protein that has been implicated in a variety of functions including peptide loading of MHC class II molecules, protection of class II MHC peptide complexes in the endocytic pathway, and signal transduction. It also interacts with other proteins, such as Invariant chain and Major Histocompatibility Complex.
Related Terms
- Cluster of Differentiation: A protocol used for the identification and investigation of cell surface molecules present on leukocytes.
- Invariant chain: A polypeptide involved in the formation and transport of MHC class II protein.
- Major Histocompatibility Complex: A set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates.
See Also
- CD4: A glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
- CD8: A transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR).
External links
- Medical encyclopedia article on CD74
- Wikipedia's article - CD74
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski