TNFRSF19

TNFRSF19, also known as TROY, is a member of the TNF-receptor superfamily. This protein is highly expressed in nervous tissue and plays a crucial role in the axon guidance and neuron survival.

Structure

TNFRSF19 is a type I transmembrane protein that contains one TNFR-Cys repeat, a common structural motif found in proteins of the TNF-receptor superfamily. The TNFR-Cys repeat is involved in ligand binding and receptor multimerization.

Function

TNFRSF19 is a receptor for tumor necrosis factor (ligand) superfamily, member 19 (TNFSF19). It is involved in the regulation of neuronal survival and axon growth. The interaction between TNFRSF19 and its ligand, TNFSF19, activates the NF-kappaB pathway, which plays a key role in regulating the immune response to infection.

Clinical significance

Mutations in the TNFRSF19 gene have been associated with various neurological disorders, including Alzheimer's disease and Parkinson's disease. Further research is needed to fully understand the role of TNFRSF19 in these diseases.

See also

• TNF receptor
• TNF superfamily

References

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