Interferon gamma receptor 2

Interferon gamma receptor 2 (IFNGR2) is a protein that in humans is encoded by the IFNGR2 gene. It is a part of the interferon system that defends the body against viral infections and cancer.

Structure

The IFNGR2 gene is located on the chromosome 21q22.11. The protein encoded by this gene is an integral part of the cell membrane and is a component of the interferon gamma receptor complex.

Function

Interferon gamma receptor 2 is involved in the biological activity of interferon gamma. Interferon gamma is a cytokine that plays a crucial role in immune response against viral infections and tumor control. The binding of interferon gamma to the receptors activates an intracellular signaling pathway that leads to numerous immunomodulatory effects.

Clinical significance

Mutations in the IFNGR2 gene have been associated with susceptibility to mycobacterium infections and increased risk of severe tuberculosis. In addition, mutations in this gene are associated with Mendelian susceptibility to mycobacterial disease.

See also

• Interferon gamma receptor 1
• Interferon gamma

External links

• GeneCards - IFNGR2