CD44

From WikiMD's WELLNESSPEDIA

CD44 is a cell surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 is expressed in a large number of mammalian cell types.

Function[edit]

CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44 is also involved in inflammation and immune response.

Clinical significance[edit]

CD44 has been identified as a gene associated with cancer progression and metastatic disease. Aberrant expression of the CD44 gene is linked to a variety of diseases, including breast cancer, colorectal cancer, and gastric cancer.

See also[edit]

References[edit]


External links[edit]

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