CCR4
CCR4
CCR4 (pronounced "C-C-R-four") is a gene that encodes a protein known as CC chemokine receptor type 4. This protein is a part of the G protein-coupled receptor family, and it plays a crucial role in the immune system.
Etymology
The term CCR4 is an abbreviation for CC chemokine receptor type 4. The "CC" refers to the two adjacent cysteines (amino acids) in the protein structure, while "chemokine receptor" refers to the protein's function as a receptor for chemokines, a type of signaling molecule involved in the immune response.
Function
The CCR4 protein is expressed on the surface of certain types of immune cells, including T cells and macrophages. It binds to specific chemokines, triggering a response that can include cell migration, activation, or proliferation. This makes it an important player in the body's immune response to infection and inflammation.
Related Terms
- Chemokine: A type of signaling molecule involved in the immune response.
- G protein-coupled receptor: A large family of proteins that includes CCR4 and plays a crucial role in cell signaling.
- T cell: A type of white blood cell that plays a central role in the immune response.
- Macrophage: A type of immune cell that engulfs and destroys pathogens and other foreign substances.
- Inflammation: A protective response by the body to injury or infection, characterized by redness, heat, swelling, and pain.
See Also
- CCR5: A related chemokine receptor that also plays a role in the immune response.
- Chemokine receptor: A type of protein on the surface of cells that binds to chemokines.
External links
- Medical encyclopedia article on CCR4
- Wikipedia's article - CCR4
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