Basigin

Basigin is a protein that in humans is encoded by the BSG gene. It is also known as CD147, EMMPRIN (extracellular matrix metalloproteinase inducer), or TCSF (tumor cell-derived collagenase-stimulatory factor).

Function

Basigin is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta chain. This protein plays a role in the development, physiology, and pathology of the nervous system and in the immune response. Basigin is a glycoprotein with different forms resulting from different modes of transcription.

Clinical significance

Basigin has been shown to stimulate the production and release of matrix metalloproteinase (MMP) in neighboring fibroblasts and it is used by many cancer cells to induce the production of these enzymes and degrade the extracellular matrix to facilitate invasion and metastasis. It is overexpressed in many tumor types and is associated with poor prognosis.

Interactions

Basigin has been shown to interact with Caveolin 1 and Glycoprotein M6A.

See also

• Cluster of differentiation
• Matrix metalloproteinase
• Caveolin 1
• Glycoprotein M6A

References

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External links

• Basigin at the US National Library of Medicine Medical Subject Headings (MeSH)