Berylliosis

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Berylliosis
Synonyms	Chronic beryllium disease (CBD)
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Specialty	Pulmonology
Symptoms	Cough, shortness of breath, fatigue, fever, night sweats, weight loss
Complications	Pulmonary hypertension, cor pulmonale, respiratory failure
Onset	Months to years after exposure
Duration	Long-term
Types	N/A
Causes	Exposure to beryllium
Risks	Occupational exposure in industries such as aerospace, nuclear power, and electronics
Diagnosis	Chest X-ray, CT scan, lung biopsy, beryllium lymphocyte proliferation test
Differential diagnosis	Sarcoidosis, tuberculosis, hypersensitivity pneumonitis
Prevention	Avoidance of beryllium exposure
Treatment	Corticosteroids, oxygen therapy, lung transplantation
Medication	N/A
Prognosis	Variable; can be progressive
Frequency	Rare
Deaths	N/A

Unusual inclusions in giant cells

Chronic berylliosis

Chronic beryllioisis

Berylliosis is a lung disease that affects people that work with metals.

Causes of Berylliosis

Berylliosis is a disease of the lungs caused by inhalation of beryllium dusts, vapors, or its compounds or implantation of the substance in the skin.

Risk factors

The toxic effects of beryllium are due to occupational exposure as Beryllium is a metallic element used in many industries, including electronics, high-technology ceramics, metals extraction, and dental alloy preparation.

Types of Berylliosis

There are two forms of beryllium-induced lung disease, acute and chronic.

Acute berylliosis

Acute berylliosis has a sudden, rapid onset and is characterized by severe inflammation of the lungs (pneumonitis), coughing, increasing breathlessness (dyspnea), and other associated symptoms and findings. In addition, in some individuals, the skin or the eyes may be affected.

Chronic berylliosis

The more common, chronic form of the disease develops more slowly and, in some cases, may not become apparent for many years after initial beryllium exposure.

Clinical features

Chronic berylliosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) within certain tissues and organs and widespread scarring and thickening of deep lung tissues (interstitial pulmonary fibrosis).

Other areas affected

Granuloma development primarily affects the lungs but other such as skin or the liver can also be affected with granulomas.

Signs & Symptoms

Acute berylliosis presents with severe inflammation of the lungs (pneumonitis), sudden onset of coughing, and difficulties breathing (dyspnea) in most patients while others may have sore throat (pharyngitis); inflammation of the mucous membranes of the nose (rhinitis) and associated nasal discharge; and inflammation of the windpipe and air passages of the lungs (tracheobronchitis).

Standard Therapies

Treatment - prevention Employees should follow all workplace and safety guidelines and take any additional, appropriate steps to reduce their exposure to beryllium dust particles, fumes, and vapors. Employees change out of their work clothing and shoes, shower, and change into street clothing. Treatment - those affected The treatment of individuals with acute berylliosis may include therapy with corticosteroid drugs, breathing support (such as the use of ventilators), and/or other supportive measures. With prompt, appropriate treatment, most affected individuals have a complete recovery with no residual effects.

Investigational Therapies

Researchers are conducting clinical trials to determine the effectiveness of a drug called infliximab (Remicade) in chronic beryllium disease (CBD). This drug may reduce tumor necrosis factor-alpha (TNF-a), which is associated with more severe disease and inflammation in the lung. Receiving infliximab may help with symptoms, and may improve clinical testing data normally ordered by your doctor, such as breathing tests. Investigators are studying the effectiveness of corticosteroid pulse therapy in individuals with chronic beryllium disease. In one case reported in the medical literature, this therapy improved pulmonary function tests and blood gases also improved. More research is necessary to determine the long-term safety and effectiveness of this treatment for individuals with chronic beryllium disease.

Other names

• Acute Beryllium Disease
• Beryllium Granulomatosis
• Beryllium Pneumonosis
• Beryllium Poisoning

External links

• Wikipedia

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