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[[File:Chronic beryllioisis - Case 293 (15528999565).jpg|alt=Chronic beryllioisis |thumb|'''Chronic beryllioisis''' ]]Berylliosis is a [[lung disease]] that affects people that work with metals. | {{SI}} | ||
{{Infobox medical condition | |||
| name = Berylliosis | |||
| image = [[File:Chronic_berylliosis_(8054314225).jpg|alt=Chest X-ray of a patient with chronic berylliosis]] | |||
| caption = Chest X-ray of a patient with chronic berylliosis | |||
| synonyms = Chronic beryllium disease (CBD) | |||
| pronounce = | |||
| specialty = [[Pulmonology]] | |||
| symptoms = [[Cough]], [[shortness of breath]], [[fatigue (medical)|fatigue]], [[fever]], [[night sweats]], [[weight loss]] | |||
| complications = [[Pulmonary hypertension]], [[cor pulmonale]], [[respiratory failure]] | |||
| onset = Months to years after exposure | |||
| duration = Long-term | |||
| causes = Exposure to [[beryllium]] | |||
| risks = Occupational exposure in industries such as [[aerospace]], [[nuclear power]], and [[electronics]] | |||
| diagnosis = [[Chest X-ray]], [[CT scan]], [[lung biopsy]], [[beryllium lymphocyte proliferation test]] | |||
| differential = [[Sarcoidosis]], [[tuberculosis]], [[hypersensitivity pneumonitis]] | |||
| prevention = Avoidance of beryllium exposure | |||
| treatment = [[Corticosteroids]], [[oxygen therapy]], [[lung transplantation]] | |||
| prognosis = Variable; can be progressive | |||
| frequency = Rare | |||
}} | |||
[[File:Chronic berylliosis - Unusual inclusions in giant cells (8054315512).jpg|alt=Unusual inclusions in giant cells |'''Unusual inclusions in giant cells'''|thumb|left]] | |||
[[File:Chronic berylliosis (8054316220).jpg|alt=Chronic berylliosis|'''Chronic berylliosis'''|thumb|left]] | |||
[[File:Chronic beryllioisis - Case 293 (15528999565).jpg|alt=Chronic beryllioisis |left|thumb|'''Chronic beryllioisis''' ]]Berylliosis is a [[lung disease]] that affects people that work with metals. | |||
== Causes of {{PAGENAME}} == | == Causes of {{PAGENAME}} == | ||
Berylliosis is a [[disease]] of the [[lungs]] caused by [[inhalation]] of beryllium dusts, vapors, or its compounds or implantation of the substance in the [[skin]]. | Berylliosis is a [[disease]] of the [[lungs]] caused by [[inhalation]] of beryllium dusts, vapors, or its compounds or implantation of the substance in the [[skin]]. | ||
== Risk factors == | == Risk factors == | ||
The toxic effects of beryllium are due to occupational exposure as Beryllium is a metallic element used in many industries, including electronics, high-technology ceramics, metals extraction, and dental alloy preparation. | The toxic effects of beryllium are due to occupational exposure as Beryllium is a metallic element used in many industries, including electronics, high-technology ceramics, metals extraction, and dental alloy preparation. | ||
== Types of {{PAGENAME}} == | == Types of {{PAGENAME}} == | ||
There are two forms of beryllium-induced lung disease, acute and chronic. | There are two forms of beryllium-induced lung disease, acute and chronic. | ||
== Acute berylliosis == | == Acute berylliosis == | ||
Acute berylliosis has a sudden, rapid onset and is characterized by severe inflammation of the lungs (pneumonitis), coughing, increasing breathlessness (dyspnea), and other associated symptoms and findings. In addition, in some individuals, the skin or the eyes may be affected. | Acute berylliosis has a sudden, rapid onset and is characterized by severe inflammation of the lungs (pneumonitis), coughing, increasing breathlessness (dyspnea), and other associated symptoms and findings. In addition, in some individuals, the skin or the eyes may be affected. | ||
== Chronic berylliosis == | == Chronic berylliosis == | ||
The more common, chronic form of the disease develops more slowly and, in some cases, may not become apparent for many years after initial beryllium exposure. | The more common, chronic form of the disease develops more slowly and, in some cases, may not become apparent for many years after initial beryllium exposure. | ||
== Clinical features == | == Clinical features == | ||
Chronic berylliosis is characterized by the abnormal formation of inflammatory masses or nodules ([[granulomas]]) within certain tissues and organs and widespread scarring and thickening of deep lung tissues (interstitial pulmonary fibrosis). | Chronic berylliosis is characterized by the abnormal formation of inflammatory masses or nodules ([[granulomas]]) within certain tissues and organs and widespread scarring and thickening of deep lung tissues (interstitial pulmonary fibrosis). | ||
== Other areas affected == | == Other areas affected == | ||
Granuloma development primarily affects the lungs but other such as skin or the liver can also be affected with [[granuloma]]s. | Granuloma development primarily affects the lungs but other such as skin or the liver can also be affected with [[granuloma]]s. | ||
==== Signs & Symptoms ==== | ==== Signs & Symptoms ==== | ||
Acute berylliosis presents with severe inflammation of the lungs (pneumonitis), sudden onset of coughing, and difficulties breathing (dyspnea) in most patients while others may have sore throat (pharyngitis); inflammation of the mucous membranes of the nose (rhinitis) and associated nasal discharge; and inflammation of the windpipe and air passages of the lungs (tracheobronchitis). | Acute berylliosis presents with severe inflammation of the lungs (pneumonitis), sudden onset of coughing, and difficulties breathing (dyspnea) in most patients while others may have sore throat (pharyngitis); inflammation of the mucous membranes of the nose (rhinitis) and associated nasal discharge; and inflammation of the windpipe and air passages of the lungs (tracheobronchitis). | ||
==== Standard Therapies ==== | ==== Standard Therapies ==== | ||
'''Treatment - prevention''' | '''Treatment - prevention''' | ||
Employees should follow all workplace and safety guidelines and take any additional, appropriate steps to reduce their exposure to beryllium dust particles, fumes, and vapors. Employees change out of their work clothing and shoes, shower, and change into street clothing. | Employees should follow all workplace and safety guidelines and take any additional, appropriate steps to reduce their exposure to beryllium dust particles, fumes, and vapors. Employees change out of their work clothing and shoes, shower, and change into street clothing. | ||
'''Treatment - those affected''' | '''Treatment - those affected''' | ||
The treatment of individuals with acute berylliosis may include therapy with corticosteroid drugs, breathing support (such as the use of ventilators), and/or other supportive measures. With prompt, appropriate treatment, most affected individuals have a complete recovery with no residual effects. | The treatment of individuals with acute berylliosis may include therapy with corticosteroid drugs, breathing support (such as the use of ventilators), and/or other supportive measures. With prompt, appropriate treatment, most affected individuals have a complete recovery with no residual effects. | ||
==== Investigational Therapies ==== | ==== Investigational Therapies ==== | ||
Researchers are conducting clinical trials to determine the effectiveness of a drug called infliximab (Remicade) in chronic beryllium disease (CBD). This drug may reduce tumor necrosis factor-alpha (TNF-a), which is associated with more severe disease and inflammation in the lung. Receiving infliximab may help with symptoms, and may improve clinical testing data normally ordered by your doctor, such as breathing tests. | Researchers are conducting clinical trials to determine the effectiveness of a drug called infliximab (Remicade) in chronic beryllium disease (CBD). This drug may reduce tumor necrosis factor-alpha (TNF-a), which is associated with more severe disease and inflammation in the lung. Receiving infliximab may help with symptoms, and may improve clinical testing data normally ordered by your doctor, such as breathing tests. | ||
Investigators are studying the effectiveness of corticosteroid pulse therapy in individuals with chronic beryllium disease. In one case reported in the medical literature, this therapy improved pulmonary function tests and blood gases also improved. More research is necessary to determine the long-term safety and effectiveness of this treatment for individuals with chronic beryllium disease. | Investigators are studying the effectiveness of corticosteroid pulse therapy in individuals with chronic beryllium disease. In one case reported in the medical literature, this therapy improved pulmonary function tests and blood gases also improved. More research is necessary to determine the long-term safety and effectiveness of this treatment for individuals with chronic beryllium disease. | ||
== Other names == | == Other names == | ||
* Acute Beryllium Disease | * Acute Beryllium Disease | ||
| Line 48: | Line 52: | ||
* Beryllium Pneumonosis | * Beryllium Pneumonosis | ||
* Beryllium Poisoning | * Beryllium Poisoning | ||
== External links == | == External links == | ||
{{wp}} | {{wp}} | ||
Latest revision as of 19:50, 4 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Berylliosis | |
|---|---|
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| |
| Synonyms | Chronic beryllium disease (CBD) |
| Pronounce | |
| Specialty | Pulmonology |
| Symptoms | Cough, shortness of breath, fatigue, fever, night sweats, weight loss |
| Complications | Pulmonary hypertension, cor pulmonale, respiratory failure |
| Onset | Months to years after exposure |
| Duration | Long-term |
| Types | N/A |
| Causes | Exposure to beryllium |
| Risks | Occupational exposure in industries such as aerospace, nuclear power, and electronics |
| Diagnosis | Chest X-ray, CT scan, lung biopsy, beryllium lymphocyte proliferation test |
| Differential diagnosis | Sarcoidosis, tuberculosis, hypersensitivity pneumonitis |
| Prevention | Avoidance of beryllium exposure |
| Treatment | Corticosteroids, oxygen therapy, lung transplantation |
| Medication | N/A |
| Prognosis | Variable; can be progressive |
| Frequency | Rare |
| Deaths | N/A |
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Berylliosis is a lung disease that affects people that work with metals.
Causes of Berylliosis[edit]
Berylliosis is a disease of the lungs caused by inhalation of beryllium dusts, vapors, or its compounds or implantation of the substance in the skin.
Risk factors[edit]
The toxic effects of beryllium are due to occupational exposure as Beryllium is a metallic element used in many industries, including electronics, high-technology ceramics, metals extraction, and dental alloy preparation.
Types of Berylliosis[edit]
There are two forms of beryllium-induced lung disease, acute and chronic.
Acute berylliosis[edit]
Acute berylliosis has a sudden, rapid onset and is characterized by severe inflammation of the lungs (pneumonitis), coughing, increasing breathlessness (dyspnea), and other associated symptoms and findings. In addition, in some individuals, the skin or the eyes may be affected.
Chronic berylliosis[edit]
The more common, chronic form of the disease develops more slowly and, in some cases, may not become apparent for many years after initial beryllium exposure.
Clinical features[edit]
Chronic berylliosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) within certain tissues and organs and widespread scarring and thickening of deep lung tissues (interstitial pulmonary fibrosis).
Other areas affected[edit]
Granuloma development primarily affects the lungs but other such as skin or the liver can also be affected with granulomas.
Signs & Symptoms[edit]
Acute berylliosis presents with severe inflammation of the lungs (pneumonitis), sudden onset of coughing, and difficulties breathing (dyspnea) in most patients while others may have sore throat (pharyngitis); inflammation of the mucous membranes of the nose (rhinitis) and associated nasal discharge; and inflammation of the windpipe and air passages of the lungs (tracheobronchitis).
Standard Therapies[edit]
Treatment - prevention Employees should follow all workplace and safety guidelines and take any additional, appropriate steps to reduce their exposure to beryllium dust particles, fumes, and vapors. Employees change out of their work clothing and shoes, shower, and change into street clothing. Treatment - those affected The treatment of individuals with acute berylliosis may include therapy with corticosteroid drugs, breathing support (such as the use of ventilators), and/or other supportive measures. With prompt, appropriate treatment, most affected individuals have a complete recovery with no residual effects.
Investigational Therapies[edit]
Researchers are conducting clinical trials to determine the effectiveness of a drug called infliximab (Remicade) in chronic beryllium disease (CBD). This drug may reduce tumor necrosis factor-alpha (TNF-a), which is associated with more severe disease and inflammation in the lung. Receiving infliximab may help with symptoms, and may improve clinical testing data normally ordered by your doctor, such as breathing tests. Investigators are studying the effectiveness of corticosteroid pulse therapy in individuals with chronic beryllium disease. In one case reported in the medical literature, this therapy improved pulmonary function tests and blood gases also improved. More research is necessary to determine the long-term safety and effectiveness of this treatment for individuals with chronic beryllium disease.
Other names[edit]
- Acute Beryllium Disease
- Beryllium Granulomatosis
- Beryllium Pneumonosis
- Beryllium Poisoning
External links[edit]
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