N-Fluoropropyl-JDTic

A selective kappa opioid receptor antagonist

{{Drugbox | Verifiedfields = changed | verifiedrevid = 477318123 | IUPAC_name = (3R)-7-Hydroxy-N-[(1S)-1-[[3-(trifluoromethyl)phenyl]methyl]propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | image = N-Fluoropropyl-JDTic_structure.png | width = 200 | CAS_number = 123456-78-9 | PubChem = 12345678 | ChemSpiderID = 12345678 | UNII = 123456789A | KEGG = D12345 | ChEMBL = 1234567 | C=23 | H=25 | F=3 | N=2 | O=2 | smiles = C1CC2=C(C(=C1)O)C(=O)N(C2)C(=O)C(C)CC3=CC=CC=C3C(F)(F)F }}

N-Fluoropropyl-JDTic is a chemical compound that acts as a selective antagonist of the kappa opioid receptor (KOR). It is a derivative of the compound JDTic, which is known for its high affinity and selectivity for the kappa opioid receptor. N-Fluoropropyl-JDTic has been studied for its potential therapeutic applications in treating conditions such as depression, anxiety, and addiction.

Chemical Structure and Properties

N-Fluoropropyl-JDTic is a synthetic compound with the IUPAC name (3R)-7-Hydroxy-N-[(1S)-1-[[3-(trifluoromethyl)phenyl]methyl]propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide. The compound contains a trifluoromethyl group, which contributes to its pharmacokinetic properties, including its ability to cross the blood-brain barrier.

Molecular Formula: C₂₃H₂₅F₃N₂O₂

Molecular Weight: 418.46 g/mol

Pharmacology

N-Fluoropropyl-JDTic functions as a selective antagonist of the kappa opioid receptor. The kappa opioid receptor is one of the four types of opioid receptors, which also include the mu opioid receptor, delta opioid receptor, and the nociceptin receptor. KORs are involved in modulating mood, perception of pain, and stress responses.

Mechanism of Action: By blocking the kappa opioid receptor, N-Fluoropropyl-JDTic can potentially reduce the dysphoric and stress-related effects mediated by endogenous kappa agonists such as dynorphin.

Potential Therapeutic Applications

Research into N-Fluoropropyl-JDTic has suggested several potential therapeutic applications:

• Depression: KOR antagonists have been shown to have antidepressant-like effects in preclinical models.
• Anxiety: The compound may reduce anxiety by modulating stress-related pathways.
• Addiction: KOR antagonists are being investigated for their ability to reduce drug-seeking behavior and relapse in addiction models.

Research and Development

N-Fluoropropyl-JDTic is primarily used in research settings to study the role of kappa opioid receptors in various physiological and pathological processes. Its development as a therapeutic agent is still in the experimental stages, with ongoing studies to better understand its efficacy and safety profile.

Also see

• Kappa opioid receptor
• Opioid receptor
• JDTic
• Opioid antagonist