Delta opioid receptor
Delta Opioid Receptor
The Delta Opioid Receptor (DOR) is one of the four main types of Opioid Receptors found in the human body. Pronounced as /ˈdɛltə ˈoʊpiɔɪd rɪˈsɛptər/, the term originates from the Greek letter Delta (Δ), used in science to denote change, and the term 'Opioid Receptor', which refers to a type of protein that binds to opioids.
Function
The Delta Opioid Receptor is primarily involved in the modulation of pain perception, emotional responses, and mood disorders. It is also implicated in the regulation of reward and addiction processes.
Structure
Like all opioid receptors, the Delta Opioid Receptor is a G protein-coupled receptor (GPCR). This means it is a type of protein that spans the cell membrane and interacts with G proteins to trigger a cellular response when an opioid binds to it.
Ligands
Ligands that bind to the Delta Opioid Receptor include both endogenous and exogenous compounds. Endogenous ligands are those produced within the body, such as enkephalins. Exogenous ligands are those introduced from outside the body, such as certain analgesics and psychoactive drugs.
Clinical Significance
The Delta Opioid Receptor is a target for the development of new analgesics that may have fewer side effects than traditional opioids. It is also being studied for its potential role in treating mood disorders and addiction.
See Also
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