Para-Methoxyamphetamine: Difference between revisions

Para-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine, is a serotonin-releasing psychoactive drug of the amphetamine class. It is known for its potentially severe side effects and high toxicity relative to dose, which has led to its classification as a Schedule I drug in the United States and Schedule I in Canada under the Controlled Drugs and Substances Act.

History[edit]

PMA was first synthesized in the 1970s, and its psychoactive effects were first noted by Alexander Shulgin in his book PiHKAL. It was initially marketed as a dietary supplement but was soon classified as a controlled substance due to its high potential for abuse and the health risks associated with its use.

Pharmacology[edit]

PMA acts as a serotonin and norepinephrine releasing agent, with its primary action being on the serotonin system. This results in increased levels of these neurotransmitters in the brain, leading to feelings of euphoria, increased energy, and altered perception. However, PMA is also known to inhibit the body's ability to regulate temperature, which can lead to severe hyperthermia and potentially fatal overheating.

Effects[edit]

The effects of PMA are similar to those of other amphetamines, but with a significantly higher risk of severe side effects. These can include hyperthermia, seizures, heart failure, and death. Due to its high toxicity, PMA is often associated with overdose deaths, particularly when it is mistaken for other less potent amphetamines like MDMA.

Legal Status[edit]

PMA is classified as a Schedule I drug in the United States, meaning it has a high potential for abuse and no accepted medical use. It is also illegal in many other countries, including Canada, Australia, and the United Kingdom.

See Also[edit]

Psychoactive substances

Stimulants	* Amphetamine Caffeine Cocaine Methamphetamine Nicotine
Depressants	* Alcohol Barbiturate Benzodiazepine Cannabis Opiate Opioid
Hallucinogens	* LSD Mescaline Psilocybin DMT Salvia divinorum
Dissociatives	* Ketamine PCP Nitrous oxide DXM
Inhalants	* Solvent Gasoline Nitrites

This psychoactive substance-related article is a stub.

Phenethylamines

Phenethylamines	* Psychedelics: 25B-NBOMe 25C-NBOMe 25D-NBOMe 25I-NBOMe 25N-NBOMe 2C-B 2C-B-AN 2C-Bn 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-G 2C-G-1 2C-G-2 2C-G-3 2C-G-4 2C-G-5 2C-G-6 2C-G-N 2C-H 2C-I 2C-iP 2C-N 2C-NH2 2C-O 2C-O-4 2C-P 2C-Ph 2C-SE 2C-T 2C-T-2 2C-T-3 2C-T-4 2C-T-5 2C-T-6 2C-T-7 2C-T-8 2C-T-9 2C-T-10 2C-T-11 2C-T-12 2C-T-13 2C-T-14 2C-T-15 2C-T-16 2C-T-17 2C-T-18 2C-T-19 2C-T-20 2C-T-21 2C-T-22 2C-T-22.5 2C-T-23 2C-T-24 2C-T-25 2C-T-27 2C-T-28 2C-T-30 2C-T-31 2C-T-32 2C-T-33 2C-TFE 2C-TFM 2C-YN 2C-V Allylescaline DESOXY Escaline Isoproscaline Jimscaline Macromerine MEPEA Mescaline Metaescaline Methallylescaline Proscaline Psi-2C-T-4 TCB-2 Stimulants: Phenylethanolamine Hordenine Phenethylamine Phenpromethamine α-Methylphenethylamine (amphetamine) β-Methylphenethylamine m-Methylphenethylamine N-Methylphenethylamine o-Methylphenethylamine p-Methylphenethylamine Methylphenidate Entactogens: Lophophine MDPEA MDMPEA Others: BOH DMPEA
Amphetamines	* Psychedelics: 3C-AL 3C-BZ 3C-E 3C-MAL 3C-P Aleph Beatrice Bromo-DragonFLY D-Deprenyl DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA-2 Psi-DOM TMA TeMA ZDCM-04 Stimulants: 2-FA 2-FMA 3-FA 3-FMA Acridorex Alfetamine Amfecloral Amfepentorex Amphetamine (Dextroamphetamine, Levoamphetamine) Amphetaminil Benfluorex Benzphetamine Cathine Clobenzorex Dimethylamphetamine Ephedrine Etilamfetamine Fencamfamin Fencamine Fenethylline Fenfluramine (Dexfenfluramine, Levofenfluramine) Fenproporex Flucetorex Fludorex Formetorex Furfenorex Gepefrine 4-Hydroxyamphetamine Iofetamine Isopropylamphetamine Lefetamine Lisdexamfetamine Mefenorex Metaraminol Methamphetamine (Dextromethamphetamine, Levomethamphetamine) Methoxyphenamine MMA Morforex Norfenfluramine L -Norpseudoephedrine N,alpha-Diethylphenylethylamine Oxifentorex Oxilofrine Ortetamine PBA PCA PFA PFMA PIA PMA PMEA PMMA Phenylpropanolamine Pholedrine Prenylamine Propylamphetamine Pseudoephedrine Sibutramine Tiflorex Tranylcypromine Xylopropamine Zylofuramine Entactogens: 4-FA 4-FMA 4-MA 4-MMA 4-MTA 5-APB 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-Chloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamine) MDEA MDHMA MDMA (midomafetamine) MDOH Methamnetamine MMDMA Naphthylaminopropane TAP Others: 3,4-DCA Amiflamine DiFMDA Selegiline (also D -Deprenyl)
Phentermines	* Stimulants: Chlorphentermine Cloforex Clortermine Etolorex Mephentermine Pentorex Phentermine Entactogens: MDPH MDMPH Others: Cericlamine
Cathinones	* Stimulants: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramone Benzedrone Brephedrone Buphedrone Bupropion Cathinone Dimethylcathinone Ethcathinone Eutylone Hydroxybupropion Methcathinone Methedrone NEB N-Ethylhexedrone N-Ethylpentedrone Pentedrone Pentylone Radafaxine Entactogens: 3,4-DMMC 3-MMC Butylone Ethylone Methylone Methylenedioxycathinone Mephedrone
Phenylisobutylamines	* Entactogens: 4-CAB 4-MAB Ariadne BDB Butylone EBDB Eutylone MBDB Stimulants: Phenylisobutylamine

Serotonin releasing agents

Phenethylamines	* Amphetamine MDMA Methamphetamine MBDB Methylone Mephedrone 4-Methylaminorex Para-Methoxyamphetamine Fenfluramine Chlorphentermine Trazodone
Tryptamines	* Alpha-Methyltryptamine 5-MeO-DIPT Sumatriptan
Lysergamides	* LSD ALD-52
Others	* Cocaine Dextromethorphan Tramadol Meperidine UWA-101

This serotonin releasing agents related article is a stub.

This article is a stub related to pharmacology. You can help WikiMD by expanding it!

Para-Methoxyamphetamine
Para-Methoxyamphetamine

@@ Line 32: / Line 32: @@
 [[Category:Serotonin releasing agents]]
 {{drug-stub}}
+<gallery>
+File:PMA.svg|Para-Methoxyamphetamine
+File:4-Methoxyamphetamine molecule ball.png|Para-Methoxyamphetamine
+</gallery>