25I-NBOMe

25I-NBOMe, also known as 2C-I-NBOMe, Cimbi-5, and NBOMe-2C-I, is a synthetic psychedelic of the phenethylamine class. It was discovered in 2003 by Ralf Heim at the Free University of Berlin and subsequently investigated by a team at Purdue University led by David E. Nichols.

Chemical structure and properties

Chemical structure of 25I-NBOMe

25I-NBOMe is a derivative of the phenethylamine 2C-I, with a methoxybenzyl group added to the nitrogen atom. This modification significantly increases its potency as a serotonin receptor agonist. The compound is known for its high affinity for the 5-HT2A receptor, which is believed to be responsible for its psychedelic effects.

The chemical formula of 25I-NBOMe is C18H22INO3, and it has a molar mass of 427.28 g/mol. It is typically encountered as a white powder or as a liquid solution.

Pharmacology

25I-NBOMe acts primarily as a potent agonist of the 5-HT2A receptor, similar to other psychedelics such as LSD and psilocybin. It also has affinity for the 5-HT2C and 5-HT2B receptors, although its effects at these sites are less well characterized. The compound is known for its intense and long-lasting effects, which can include visual hallucinations, altered perception of time, and changes in mood and thought processes.

Effects

The effects of 25I-NBOMe can vary widely depending on the dose, the individual, and the setting. Common effects include:

• Visual and auditory hallucinations
• Euphoria
• Altered sense of time
• Enhanced sensory perception
• Synesthesia

However, the drug can also cause negative effects, such as anxiety, confusion, and paranoia. Due to its potency, there is a significant risk of overdose, which can lead to severe health complications or death.

Legal status

25I-NBOMe is classified as a Schedule I substance in the United States, meaning it is considered to have a high potential for abuse and no accepted medical use. It is also controlled in many other countries, including the United Kingdom, Canada, and Australia.

Safety and toxicity

Space-filling model of 25I-NBOMe

The safety profile of 25I-NBOMe is not well established, but it is known to be highly potent and potentially dangerous. There have been numerous reports of hospitalizations and fatalities associated with its use. The risk of overdose is particularly high due to the difficulty in accurately measuring doses, especially when the drug is sold on blotter paper.

Related pages

• Psychedelic drug
• Phenethylamine
• Serotonin receptor
• 2C-I
• LSD