2C-E

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2C-E is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and described in his book PiHKAL (Phenethylamines I Have Known And Loved). The full chemical name of 2C-E is 2,5-dimethoxy-4-ethylphenethylamine.

Chemistry

2C-E is a substituted phenethylamine, which means it has a phenyl ring bound to an amino (NH2) group through an ethyl chain. The structure of 2C-E includes methoxy groups (–OCH3) at the 2 and 5 positions of the phenyl ring, and an ethyl group at the 4 position.

Pharmacology

2C-E acts as a serotonin receptor agonist, primarily affecting the 5-HT2A receptor. This action is responsible for its psychedelic effects. The compound is known for its potency and long duration of action, typically lasting between 8 to 12 hours.

Effects

The effects of 2C-E are similar to other psychedelics such as LSD and psilocybin. Users report intense visual hallucinations, altered perception of time, and profound changes in thought processes. The intensity of the experience can vary significantly depending on the dose.

Dosage

The active dose of 2C-E is typically in the range of 10 to 20 milligrams. Due to its potency, it is important to measure doses accurately to avoid overdose and adverse effects.

Legal Status

The legal status of 2C-E varies by country. In some places, it is classified as a controlled substance, while in others it remains legal or unregulated. It is important to check local laws before possessing or using 2C-E.

Safety and Risks

As with other psychedelics, the use of 2C-E carries potential risks, including psychological distress, anxiety, and the possibility of triggering latent mental health issues. It is advised to use 2C-E in a safe and controlled environment, preferably with a sober sitter present.

See Also

References



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Contributors: Prab R. Tumpati, MD