25B-NBOMe
25B-NBOMe
25B-NBOMe, also known as 2C-B-NBOMe, is a synthetic psychedelic compound belonging to the NBOMe class. It is a derivative of the phenethylamine 2C-B, and is known for its potent hallucinogenic effects. The compound was first synthesized in the early 2000s and has been used in scientific research to study the serotonin receptor system.
Chemical Structure and Properties
25B-NBOMe is chemically related to the 2C family of phenethylamines, with the addition of a 2-methoxybenzyl (NBOMe) group to the nitrogen atom. This modification significantly increases the compound's affinity for the 5-HT2A receptor, which is primarily responsible for its psychedelic effects.
The chemical formula of 25B-NBOMe is C18H22BrNO3, and it has a molecular weight of 380.28 g/mol. The presence of the bromine atom in its structure distinguishes it from other NBOMe compounds such as 25I-NBOMe and 25C-NBOMe.
Pharmacology
25B-NBOMe acts as a potent agonist at the 5-HT2A receptor, which is a subtype of the serotonin receptor found in the central nervous system. Activation of this receptor is known to produce hallucinogenic effects, which are characteristic of many psychedelic substances.
The compound is typically active at very low doses, often in the microgram range, making it one of the most potent psychedelics known. Its effects can include visual and auditory hallucinations, altered perception of time, and changes in mood and thought processes.
Legal Status
The legal status of 25B-NBOMe varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is important for researchers and users to be aware of the legal implications of possessing or distributing this compound.
Safety and Toxicity
The safety profile of 25B-NBOMe is not well-established, and there have been reports of adverse effects and fatalities associated with its use. These effects may include vasoconstriction, tachycardia, hypertension, and seizures. Due to its high potency, there is a significant risk of overdose, especially when the compound is misidentified or improperly dosed.
Related Compounds
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Contributors: Prab R. Tumpati, MD