Template:Opioid receptor modulators: Difference between revisions
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{{Navbox | {{Navbox | ||
| name = Opioid receptor modulators | | name = Opioid receptor modulators | ||
| title = [[Opioid receptor]] [[receptor modulator| | | title = [[Opioid receptor]] [[receptor modulator|modulators]] | ||
| state = {{{state<includeonly>|collapsed</includeonly>}}} | | state = {{{state<includeonly>|collapsed</includeonly>}}} | ||
| listclass = hlist | | listclass = hlist | ||
| groupstyle = text-align:center; | | groupstyle = text-align:center; | ||
| group1 = | | group1 = [[μ-opioid receptor|μ-opioid]]<br>(MOR) | ||
| list1 = | | list1 = | ||
{{Navbox|child | |||
|group1=Agonists<br>(abridged;<br>[[list of opioids|full list]])<!-- Please add MOR agonists sparingly! Preferably notable, marketed, and/or atypical MOR agonists only. --> | |||
|list1= | |||
* [[3-HO-PCP]] | |||
* [[7-Acetoxymitragynine]] | * [[7-Acetoxymitragynine]] | ||
* [[7-Hydroxymitragynine]] | * [[7-Hydroxymitragynine]] | ||
* [[ψ-Akuammigine]] | * [[ψ-Akuammigine]] | ||
* [[Chlornaltrexamine|α-Chlornaltrexamine]]<!-- | * [[Chlornaltrexamine|α-Chlornaltrexamine]]<!-- irreversible --> | ||
* [[alpha-Narcotine|α-Narcotine]] | * [[alpha-Narcotine|α-Narcotine]] | ||
* [[Acetyldihydrocodeine]] | * [[Acetyldihydrocodeine]] | ||
| Line 41: | Line 44: | ||
* [[Casokefamide]] | * [[Casokefamide]] | ||
* [[Cebranopadol]] | * [[Cebranopadol]] | ||
* [[Chloroxymorphamine]]<!-- | * [[Chloroxymorphamine]]<!-- irreversible --> | ||
* [[Codeine]] | * [[Codeine]] | ||
* [[DADLE]] | * [[DADLE]] | ||
* [[DAMGO|DAMGO (DAGO)]] | * [[DAMGO|DAMGO (DAGO)]] | ||
* [[Dermorphin]] | * [[Dermorphin]] | ||
* [[Desmetramadol | * [[Desmetramadol]] (desmethyltramadol) | ||
* [[Desomorphine]] | * [[Desomorphine]] | ||
* [[Deumitragynine]] | |||
* [[Dextromoramide]] | * [[Dextromoramide]] | ||
* [[Dextropropoxyphene | * [[Dextropropoxyphene]] (propoxyphene) | ||
* [[Dezocine]] | * [[Dezocine]] | ||
* [[Dimenoxadol]] | * [[Dimenoxadol]] | ||
* [[Dimethylaminopivalophenone]] | * [[Dimethylaminopivalophenone]] | ||
* [[Eluxadoline]] | * [[Eluxadoline]] | ||
* [[Heroin|Diamorphine (heroin) | * [[Heroin|Diamorphine]] (heroin) | ||
* [[Dihydrocodeine]] | * [[Dihydrocodeine]] | ||
* [[Dihydroetorphine]] | * [[Dihydroetorphine]] | ||
| Line 91: | Line 95: | ||
* [[Loperamide]] | * [[Loperamide]] | ||
* [[Loxicodegol]] | * [[Loxicodegol]] | ||
* [[LS-115509]] | |||
* [[Matrine]] | * [[Matrine]] | ||
* [[Meptazinol]] | * [[Meptazinol]] | ||
* [[Met-enkephalin | * [[Met-enkephalin]] (metenkefalin) | ||
* [[Methadone]] | * [[Methadone]] | ||
* [[Metkefamide]] | * [[Metkefamide]] | ||
| Line 102: | Line 107: | ||
* [[Morphine]] | * [[Morphine]] | ||
* [[Nalbuphine]] | * [[Nalbuphine]] | ||
* [[Naloxone benzoylhydrazone | * [[Naloxone benzoylhydrazone]] (NalBzOH) | ||
* [[Nalmexone]] | * [[Nalmexone]] | ||
* [[Naltalimide]] | * [[Naltalimide]] | ||
| Line 110: | Line 115: | ||
* [[Nicodicodine]] | * [[Nicodicodine]] | ||
* [[Nicomorphine]] | * [[Nicomorphine]] | ||
* [[Norketamine]] | * [[Norketamine]] | ||
* [[Nufenoxole]] | |||
* [[Octreotide]] | * [[Octreotide]] | ||
* [[Oliceridine]] | * [[Oliceridine]] | ||
* [[Oxymorphone-3-methoxynaltrexonazine | * [[Oxycodegol]] | ||
* [[Oxymorphone-3-methoxynaltrexonazine]] (OM-3-MNZ) | |||
* [[Oripavine]] | * [[Oripavine]] | ||
* [[Oxycodone]] | * [[Oxycodone]] | ||
* [[Oxymorphazone]]<!-- | * [[Oxymorphazone]]<!-- irreversible --> | ||
* [[Oxymorphonazine]]<!-- | * [[Oxymorphonazine]]<!-- irreversible --> | ||
* [[Oxymorphone]] | * [[Oxymorphone]] | ||
* [[Oxymorphone phenylhydrazone]]<!-- | * [[Oxymorphone phenylhydrazone]]<!-- irreversible --> | ||
* [[Oxymorphone p-nitrophenylhydrazone|OxyPNPH]]<!-- | * [[Oxymorphone p-nitrophenylhydrazone|OxyPNPH]]<!-- irreversible --> | ||
* ''[[Papaver somniferum]]'' ([[opium]]) | * ''[[Papaver somniferum]]'' ([[opium]]) | ||
* [[Pentazocine]] | * [[Pentazocine]] | ||
| Line 158: | Line 164: | ||
* [[Xorphanol]] | * [[Xorphanol]] | ||
<!-- |list2= ''PAMs:'' | |||
* [[BMS-986122]] | |group2= | ||
* [[BMS-986121]] | |||
* [[BMS-986122]] --> | |||
* | |group3= Antagonists | ||
|list3= | |||
* [[Picenadol|(3S,4S)-Picenadol]] | |||
* [[Viminol|2-(S)-N,N-(R)-Viminol]] | * [[Viminol|2-(S)-N,N-(R)-Viminol]] | ||
* [[3CS-nalmefene]]<!--3-Carboxamido seco-nalmefene; https:// | * [[3CS-nalmefene]]<!-- 3-Carboxamido seco-nalmefene; https://pubmed.ncbi.nlm.nih.gov/28844812/ --> | ||
* [[4-Caffeoyl-1,5-quinide]] | * [[4-Caffeoyl-1,5-quinide]] | ||
* [[4′-Hydroxyflavanone]] | * [[4′-Hydroxyflavanone]] | ||
| Line 171: | Line 181: | ||
* [[18-Methoxycoronaridine|18-MC]] | * [[18-Methoxycoronaridine|18-MC]] | ||
* [[alpha-Gliadin|α-Gliadin]] | * [[alpha-Gliadin|α-Gliadin]] | ||
* [[Chlornaltrexamine|β-Chlornaltrexamine]]<!-- | * [[Chlornaltrexamine|β-Chlornaltrexamine]]<!-- irreversible --> | ||
* [[beta-Funaltrexamine|β-Funaltrexamine]]<!-- | * [[beta-Funaltrexamine|β-Funaltrexamine]]<!-- irreversible --> | ||
* [[Akuammine]] | * [[Akuammine]] | ||
* [[Alvimopan]] | * [[Alvimopan]] | ||
| Line 182: | Line 192: | ||
* [[Catechin]] | * [[Catechin]] | ||
* [[Epicatechin gallate|Catechin gallate]] | * [[Epicatechin gallate|Catechin gallate]] | ||
* [[Clocinnamox]]<!-- | * [[Clocinnamox]]<!-- irreversible --> | ||
* | * CTAP | ||
* [[CTOP]] | * [[CTOP]] | ||
* [[Cyclofoxy]]<!--6-Deoxy-6β-fluoronaltrexone; MOR- and KOR-selective antagonist radiotracer; PMID: 2825063--> | * [[Cyclofoxy]]<!-- 6-Deoxy-6β-fluoronaltrexone; MOR- and KOR-selective antagonist radiotracer; PMID: 2825063 --> | ||
* [[Cyprodime]] | * [[Cyprodime]] | ||
* [[Diacetylnalorphine]] | * [[Diacetylnalorphine]] | ||
* [[Diprenorphine]] | * [[Diprenorphine]] | ||
* [[Epicatechin gallate|ECG]] | * [[Epicatechin gallate|ECG]] | ||
* [[ | * [[Gallocatechol|EGC]] | ||
* [[Epicatechin]] | * [[Epicatechin]] | ||
* [[Eptazocine]] | * [[Eptazocine]] | ||
| Line 197: | Line 207: | ||
* [[Hyperoside]] | * [[Hyperoside]] | ||
* [[Ibogaine]] | * [[Ibogaine]] | ||
* [[JDTic]] | |||
* [[Levallorphan]] | * [[Levallorphan]] | ||
* [[Lobeline]] | * [[Lobeline]] | ||
* [[LY-255582]] | * [[LY-255582]] | ||
* [[LY-2196044]] | * [[LY-2196044]] | ||
* [[Methocinnamox]]<!-- | * [[Methocinnamox]]<!-- irreversible --> | ||
* [[Methylnaltrexone]] | * [[Methylnaltrexone]] | ||
* [[Methylsamidorphan chloride]] | * [[Methylsamidorphan chloride]] | ||
| Line 209: | Line 220: | ||
* [[Nalorphine]] | * [[Nalorphine]] | ||
* [[Nalorphine dinicotinate]] | * [[Nalorphine dinicotinate]] | ||
* [[Naloxazone]]<!-- | * [[Naloxazone]]<!-- irreversible --> | ||
* [[Naloxegol]] | * [[Naloxegol]] | ||
* [[Naloxol]] | * [[Naloxol]] | ||
* [[Naloxonazine]]<!-- | * [[Naloxonazine]]<!-- irreversible --> | ||
* [[Naloxone]] | * [[Naloxone]] | ||
* [[Naltrexazone]]<!-- | * [[Naltrexazone]]<!-- irreversible --> | ||
* [[Naltrexonazine]]<!-- | * [[Naltrexonazine]]<!-- irreversible --> | ||
* [[Naltrexone]] | * [[Naltrexone]] | ||
* [[Naltrindole]] | * [[Naltrindole]] | ||
| Line 226: | Line 237: | ||
* [[Samidorphan]] | * [[Samidorphan]] | ||
* [[Taxifolin]] | * [[Taxifolin]] | ||
<!-- | |||
|group4=Unknown/unsorted | |||
|list4= | |||
* [[Cannabidiol]] PMID: 16489449 | |||
* [[Coronaridine]] | * [[Coronaridine]] | ||
* [[Dihydroakuuamine]] | * [[Dihydroakuuamine]] | ||
* [[Tabernanthine]] | * [[Tabernanthine]] | ||
* [[Tetrahydrocannabinol]] | * [[Tetrahydrocannabinol]] PMID: 16489449 --> | ||
}} | |||
| group2 = | | group2 = [[δ-opioid receptor|δ-opioid]]<br>(DOR) | ||
| list2 = | | list2 = | ||
* | {{Navbox|child | ||
|group1=Agonists | |||
|list1= | |||
* [[3CS-nalmefene]]<!-- 3-Carboxamido seco-nalmefene; https://pubmed.ncbi.nlm.nih.gov/28844812/ --> | |||
* [[6'-Guanidinonaltrindole|6'-GNTI]] | * [[6'-Guanidinonaltrindole|6'-GNTI]] | ||
* [[7-Spiroindanyloxymorphone|7-SIOM]] | * [[7-Spiroindanyloxymorphone|7-SIOM]] | ||
| Line 243: | Line 259: | ||
* [[Alazocine|Alazocine (SKF-10047)]] | * [[Alazocine|Alazocine (SKF-10047)]] | ||
* [[Amoxapine]] | * [[Amoxapine]] | ||
* [[ | * [[ARM390|AR-M100390 (ARM390)]] | ||
* [[AZD2327]] | * [[AZD2327]] | ||
* [[Beta-Endorphin|β-Endorphin]] | * [[Beta-Endorphin|β-Endorphin]] | ||
| Line 273: | Line 289: | ||
* [[Etorphine]] | * [[Etorphine]] | ||
* [[Fentanyl]] | * [[Fentanyl]] | ||
* [[Fentanyl isothiocyanate|FIT]]<!-- | * [[Fentanyl isothiocyanate|FIT]]<!-- irreversible --> | ||
* [[Fluorophen]] | * [[Fluorophen]] | ||
* [[Hemorphin-4]] | * [[Hemorphin-4]] | ||
| Line 281: | Line 297: | ||
* [[Isomethadone]] | * [[Isomethadone]] | ||
* [[JNJ-20788560]] | * [[JNJ-20788560]] | ||
* [[KNT-127]]<!--Antidepressant-like and antinociceptive effects without convulsions--> | * [[KNT-127]]<!-- Antidepressant-like and antinociceptive effects without convulsions --> | ||
* [[Mitragyna speciosa|Kratom]] | * [[Mitragyna speciosa|Kratom]] | ||
* [[Laudanosine]] | * [[Laudanosine]] | ||
| Line 320: | Line 336: | ||
* [[Zenazocine]] | * [[Zenazocine]] | ||
* | |group2=Antagonists | ||
* [[Naltrindole-5'-isothiocyanate|5'-NTII]]<!-- | |list2= | ||
* [[4',7-Dihydroxyflavone]] | |||
* [[Naltrindole-5'-isothiocyanate|5'-NTII]]<!-- irreversible --> | |||
* [[6β-Naltrexol]] | * [[6β-Naltrexol]] | ||
* [[6β-Naltrexol-d4]] | * [[6β-Naltrexol-d4]] | ||
* [[alpha-Santolol|α-Santolol]] | * [[alpha-Santolol|α-Santolol]] | ||
* [[Chlornaltrexamine|β-Chlornaltrexamine]]<!-- | * [[Chlornaltrexamine|β-Chlornaltrexamine]]<!-- irreversible --> | ||
* [[Apigenin]] | * [[Apigenin]] | ||
* [[AT-076]] | * [[AT-076]] | ||
* [[Axelopran]] | * [[Axelopran]] | ||
* [[Bevenopran]] | * [[Bevenopran]] | ||
* [[7-Benzylidenenaltrexone|BNTX]]<!-- | * [[7-Benzylidenenaltrexone|BNTX]]<!-- selective δ1 antagonist --> | ||
* [[Catechin]] | * [[Catechin]] | ||
* [[Epicatechin gallate|Catechin gallate]] | * [[Epicatechin gallate|Catechin gallate]] | ||
| Line 337: | Line 355: | ||
* [[Diprenorphine]] | * [[Diprenorphine]] | ||
* [[Epicatechin gallate|ECG]] | * [[Epicatechin gallate|ECG]] | ||
* [[ | * [[Gallocatechol|EGC]] | ||
* [[Eluxadoline]] | * [[Eluxadoline]] | ||
* [[Epicatechin]] | * [[Epicatechin]] | ||
| Line 345: | Line 363: | ||
* [[LY-2196044]] | * [[LY-2196044]] | ||
* [[Methylnaltrexone]] | * [[Methylnaltrexone]] | ||
* [[Methylnaltrindole]]<!--MeNTI; DOR-selective antagonist radiotracer--> | * [[Methylnaltrindole]]<!-- MeNTI; DOR-selective antagonist radiotracer --> | ||
* [[N-Benzylnaltrindole]] | * [[N-Benzylnaltrindole]] | ||
* [[Nalmefene]] | * [[Nalmefene]] | ||
* [[Nalorphine]] | * [[Nalorphine]] | ||
* [[Naltrexone]] | * [[Naltrexone]] | ||
* [[Naltriben]]<!-- | * [[Naltriben]]<!-- selective δ2 antagonist --> | ||
* [[Naltrindole]] | * [[Naltrindole]] | ||
* [[Naloxone]] | * [[Naloxone]] | ||
| Line 361: | Line 379: | ||
* [[Taxifolin]] | * [[Taxifolin]] | ||
* [[Thienorphine]] | * [[Thienorphine]] | ||
<!-- | |||
* ''Unknown/unsorted:'' [[18-Methoxycoronaridine|18-MC]] | * ''Unknown/unsorted:'' [[18-Methoxycoronaridine|18-MC]] | ||
* [[Cannabidiol]] | * [[Cannabidiol]]PMID: 16489449 | ||
* [[Coronaridine]] | * [[Coronaridine]] | ||
* [[Tabernanthine]] | * [[Tabernanthine]] | ||
* [[Tetrahydrocannabinol]] | * [[Tetrahydrocannabinol]]PMID: 16489449 --> | ||
}} | |||
| group3 = | | group3 = [[κ-opioid receptor|κ-opioid]]<br>(KOR) | ||
| list3 = | | list3 = | ||
* | {{Navbox|child | ||
* [[6'-Guanidinonaltrindole|6'-GNTI]]<!-- | |group1=Agonists | ||
|list1= | |||
* [[3CS-nalmefene]]<!-- 3-Carboxamido seco-nalmefene; https://pubmed.ncbi.nlm.nih.gov/28844812/ --> | |||
* [[6'-Guanidinonaltrindole|6'-GNTI]]<!-- biased agonist --> | |||
* [[8-Carboxamidocyclazocine|8-CAC]] | * [[8-Carboxamidocyclazocine|8-CAC]] | ||
* [[18-Methoxycoronaridine|18-MC]] | * [[18-Methoxycoronaridine|18-MC]] | ||
| Line 379: | Line 399: | ||
* [[beta-Funaltrexamine|β-Funaltrexamine]] | * [[beta-Funaltrexamine|β-Funaltrexamine]] | ||
* [[Adrenorphin|Adrenorphin (metorphamide)]] | * [[Adrenorphin|Adrenorphin (metorphamide)]] | ||
* [[ | * [[Akuammicine]] | ||
* [[Alazocine|Alazocine (SKF-10047)]] | * [[Alazocine|Alazocine (SKF-10047)]] | ||
* [[Allomatrine]] | * [[Allomatrine]] | ||
| Line 418: | Line 438: | ||
* [[Fentanyl]] | * [[Fentanyl]] | ||
* [[Gemazocine]] | * [[Gemazocine]] | ||
* [[GR-89696]]<!-- | * [[GR-89696]]<!-- first KOR-selective agonist radiotracer --> | ||
* [[GR-103545]]<!--(–)-Isomer of GR-89696 (active isomer); first-in-humans KOR-selective agonist radiotracer--> | * [[GR-103545]]<!-- (–)-Isomer of GR-89696 (active isomer); first-in-humans KOR-selective agonist radiotracer --> | ||
* [[Hemorphin-4]] | * [[Hemorphin-4]] | ||
* [[Herkinorin]] | * [[Herkinorin]] | ||
| Line 460: | Line 480: | ||
* [[Norbuprenorphine]] | * [[Norbuprenorphine]] | ||
* [[Norbuprenorphine-3-glucuronide]] | * [[Norbuprenorphine-3-glucuronide]] | ||
* [[Noribogaine]]<!-- | * [[Noribogaine]]<!-- biased agonist --> | ||
* [[Norketamine]] | * [[Norketamine]] | ||
* [[Oripavine]] | * [[Oripavine]] | ||
| Line 471: | Line 491: | ||
* [[Methorphan|Racemethorphan]] | * [[Methorphan|Racemethorphan]] | ||
* [[Racemorphan]] | * [[Racemorphan]] | ||
* [[RB-64]]<!-- | * [[RB-64]]<!-- biased agonist --> | ||
* [[Salvinorin A]] ([[Salvia divinorum|salvia]]) | * [[Salvinorin A]] ([[Salvia divinorum|salvia]]) | ||
* [[Salvinorin B ethoxymethyl ether]] | * [[Salvinorin B ethoxymethyl ether]] | ||
* [[Salvinorin B methoxymethyl ether]] | * [[Salvinorin B methoxymethyl ether]] | ||
* [[Samidorphan]] | * [[Samidorphan]] | ||
* [[Spiradoline | * [[Spiradoline]] (U-62066) | ||
* [[TH-030418]] | * [[TH-030418]] | ||
* [[Thienorphine]] | * [[Thienorphine]] | ||
| Line 482: | Line 502: | ||
* [[Tricyclic antidepressant]]s (e.g., [[amitriptyline]], [[desipramine]], [[imipramine]], [[nortriptyline]]) | * [[Tricyclic antidepressant]]s (e.g., [[amitriptyline]], [[desipramine]], [[imipramine]], [[nortriptyline]]) | ||
* [[U-50488]] | * [[U-50488]] | ||
* [[U- | * [[U-54494A]] | ||
* [[U- | * [[U-69593]] | ||
* [[Xorphanol]] | * [[Xorphanol]] | ||
* | |group2=Antagonists | ||
|list2= | |||
* [[4′-Hydroxyflavanone]] | |||
* [[4',7-Dihydroxyflavone]] | * [[4',7-Dihydroxyflavone]] | ||
* [[5'-Guanidinonaltrindole|5'-GNTI]] | * [[5'-Guanidinonaltrindole|5'-GNTI]] | ||
* [[6'-Guanidinonaltrindole|6'-GNTI]]<!-- | * [[6'-Guanidinonaltrindole|6'-GNTI]]<!-- biased agonist --> | ||
* [[6β-Naltrexol]] | * [[6β-Naltrexol]] | ||
* [[6β-Naltrexol-d4]] | * [[6β-Naltrexol-d4]] | ||
* [[Chlornaltrexamine|β-Chlornaltrexamine]]<!-- | * [[Chlornaltrexamine|β-Chlornaltrexamine]]<!-- irreversible --> | ||
* [[Buprenorphine/samidorphan]] | * [[Buprenorphine/samidorphan]] | ||
* [[Amentoflavone]] | * [[Amentoflavone]] | ||
| Line 509: | Line 531: | ||
* [[CERC-501|CERC-501 (LY-2456302)]] | * [[CERC-501|CERC-501 (LY-2456302)]] | ||
* [[Clocinnamox]] | * [[Clocinnamox]] | ||
* [[Cyclofoxy]]<!--6-Deoxy-6β-fluoronaltrexone; MOR- and KOR-selective antagonist radiotracer; PMID: 2825063--> | * [[Icalcaprant|CVL-354]] | ||
* [[Cyclofoxy]]<!-- 6-Deoxy-6β-fluoronaltrexone; MOR- and KOR-selective antagonist radiotracer; PMID: 2825063 --> | |||
* [[Dezocine]] | * [[Dezocine]] | ||
* [[DIPPA]]<!-- | * [[DIPPA]]<!-- irreversible --> | ||
* [[ | * [[Gallocatechol|EGC]] | ||
* [[Epicatechin gallate|ECG]] | * [[Epicatechin gallate|ECG]] | ||
* [[Epicatechin]] | * [[Epicatechin]] | ||
| Line 521: | Line 544: | ||
* [[LY-2444296]] | * [[LY-2444296]] | ||
* [[LY-2459989]] | * [[LY-2459989]] | ||
* [[LY-2795050]]<!-- | * [[LY-2795050]]<!-- first KOR-selective antagonist radioligand; succeeded by LY-2459989 --> | ||
* [[MeJDTic]]<!--KOR-selective antagonist radiotracer--> | * [[MeJDTic]]<!-- KOR-selective antagonist radiotracer --> | ||
* [[Methylnaltrexone]] | * [[Methylnaltrexone]] | ||
* [[ML190]] | * [[ML190]] | ||
* [[ML350]] | * [[ML350]] | ||
* [[MR-2266]] | * [[MR-2266]] | ||
* [[N-Fluoropropyl-JDTic]]<!--KOR-selective antagonist radiotracer; | * [[N-Fluoropropyl-JDTic]]<!-- KOR-selective antagonist radiotracer; new in 2015 --> | ||
* [[Naloxone]] | * [[Naloxone]] | ||
* [[Naltrexone]] | * [[Naltrexone]] | ||
* [[Naltrindole]] | * [[Naltrindole]] | ||
* [[Naringenin]] | * [[Naringenin]] | ||
* [[Navacaprant]] | |||
* [[Norbinaltorphimine]] | * [[Norbinaltorphimine]] | ||
* [[Noribogaine]]<!-- | * [[Noribogaine]]<!-- biased agonist --> | ||
* [[Pawhuskin A]] | * [[Pawhuskin A]] | ||
* [[PF-4455242]] | * [[PF-4455242]] | ||
* [[RB-64]]<!-- | * [[RB-64]]<!-- biased agonist --> | ||
* [[Quadazocine]] | * [[Quadazocine]] | ||
* [[Taxifolin]] | * [[Taxifolin]] | ||
* [[UPHIT]]<!-- | * [[UPHIT]]<!-- irreversible --> | ||
* [[Zyklophin]] | * [[Zyklophin]] | ||
* ''Unknown/unsorted:'' [[Akuammicine]] | <!-- * ''Unknown/unsorted:'' [[Akuammicine]] | ||
* [[Akuammine]] | * [[Akuammine]] | ||
* [[Coronaridine]] | * [[Coronaridine]] | ||
* [[Dihydroakuuamine]] | * [[Dihydroakuuamine]] | ||
* [[Ibogamine]] | * [[Ibogamine]] | ||
* [[Tabernanthine]] | * [[Tabernanthine]] --> | ||
}} | |||
| group4 = | | group4 = [[Nociceptin receptor|Nociceptin]]<br>(NOP) | ||
| list4 = | | list4 = | ||
* | {{Navbox|child | ||
|group1=Agonists | |||
|list1= | |||
* [[(Arg14,Lys15)Nociceptin]] | |||
* [[((pF)Phe4)Nociceptin(1-13)NH2|((pF)Phe<sup>4</sup>)Nociceptin(1-13)NH<sub>2</sub>]] | * [[((pF)Phe4)Nociceptin(1-13)NH2|((pF)Phe<sup>4</sup>)Nociceptin(1-13)NH<sub>2</sub>]] | ||
* [[(Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2|(Phe<sup>1</sup>Ψ(CH<sub>2</sub>-NH)Gly<sup>2</sup>)Nociceptin(1-13)NH<sub>2</sub>]] | * [[(Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2|(Phe<sup>1</sup>Ψ(CH<sub>2</sub>-NH)Gly<sup>2</sup>)Nociceptin(1-13)NH<sub>2</sub>]] | ||
| Line 564: | Line 590: | ||
* [[JNJ-19385899]] | * [[JNJ-19385899]] | ||
* [[Levomethorphan]] | * [[Levomethorphan]] | ||
* [[Levorphanol]] | * [[Levorphanol]] | ||
* [[Lexanopadol]] | * [[Lexanopadol]] | ||
| Line 582: | Line 607: | ||
* [[SR-8993]] | * [[SR-8993]] | ||
* [[SR-16435]] | * [[SR-16435]] | ||
* [[Sunobinop|Sunobinop (S-117957)]] | |||
* [[TH-030418]] | * [[TH-030418]] | ||
* | |group2=Antagonists | ||
|list2= | |||
* [[(Nphe1)Nociceptin(1-13)NH2|(Nphe<sup>1</sup>)Nociceptin(1-13)NH<sub>2</sub>]] | |||
* [[AT-076]] | * [[AT-076]] | ||
* [[BAN-ORL-24]] | * [[BAN-ORL-24]] | ||
* [[BTRX-246040|BTRX-246040 (LY-2940094)]] | * [[BTRX-246040|BTRX-246040 (LY-2940094)]] | ||
* [[J- | * [[J-113397]] | ||
* [[JTC-801]] | * [[JTC-801]] | ||
* [[Naloxone benzoylhydrazone|NalBzOH]] | * [[Naloxone benzoylhydrazone|NalBzOH]] | ||
* [[Nociceptin (1-7)]] | * [[Nociceptin (1-7)]] | ||
* [[Nocistatin]] | * [[Nocistatin]] | ||
* [[SB- | * [[SB-612111]] | ||
* [[SR-16430]] | * [[SR-16430]] | ||
* [[Thienorphine]] | * [[Thienorphine]] | ||
* [[Trap-101]] | * [[Trap-101]] | ||
* [[UFP-101]] | * [[UFP-101]] | ||
}} | |||
| group5 = Unsorted | <!-- | ||
| group5 = Unsorted In some cases, unknown | |||
| list5 = | | list5 = | ||
* [[Casomorphin|β- | * [[Casomorphin|β-Casomorphins]] | ||
* [[Amidorphin]] | * [[Amidorphin]] | ||
* [[BAM-20P]] | * [[BAM-20P]] Very potent in guinea pig ileum assay | ||
* [[Cytochrophin-4]] | * [[Cytochrophin-4]] | ||
* [[Deprolorphin]] | * [[Deprolorphin]] | ||
| Line 609: | Line 638: | ||
* [[Gluten exorphin]]s | * [[Gluten exorphin]]s | ||
* [[Hemorphin]]s | * [[Hemorphin]]s | ||
* [[Kava]] constituents | * [[Kava]] constituents PMID: 11458444 | ||
* [[Met5-Enkephalin-Arg6,Phe7,Leu8|MEAGL]] | * [[Met5-Enkephalin-Arg6,Phe7,Leu8|MEAGL]] | ||
* [[Met5-Enkephalin-Arg6,Phe7|MEAP]] | * [[Met5-Enkephalin-Arg6,Phe7|MEAP]] | ||
* [[N-Ethylmaleimide|NEM]] | * [[N-Ethylmaleimide|NEM]] Irreversible | ||
* [[Neoendorphin]]s | * [[Neoendorphin]]s | ||
* [[Nepetalactone]] ([[catnip]]) | * [[Nepetalactone]] ([[catnip]]) | ||
* [[Peptide B]] | * [[Peptide B]] | ||
* [[Peptide E]] | * [[Peptide E]] Very potent in guinea pig ileum assay; verified KOR agonist | ||
* [[Peptide F]] | * [[Peptide F]] | ||
* [[Peptide I]] | * [[Peptide I]] | ||
* [[Rubiscolin]]s | * [[Rubiscolin]]s | ||
* [[Soymorphin]]s | * [[Soymorphin]]s --> | ||
| group6 = Others | | group6 = Others | ||
| Line 627: | Line 656: | ||
* [[BL-2401]] | * [[BL-2401]] | ||
* [[Candoxatril]] | * [[Candoxatril]] | ||
* [[Phenylalanine#D-, L- and DL-phenylalanine|{{ | * [[Phenylalanine#D-, L- and DL-phenylalanine|{{small|D}}-Phenylalanine]] | ||
* [[Dexecadotril|Dexecadotril (retorphan)]] | * [[Dexecadotril|Dexecadotril (retorphan)]] | ||
* [[Ecadotril|Ecadotril (sinorphan)]] | * [[Ecadotril|Ecadotril (sinorphan)]] | ||
| Line 650: | Line 679: | ||
* ''Others:'' [[Kyotorphin]] (met-enkephalin releaser/degradation stabilizer) | * ''Others:'' [[Kyotorphin]] (met-enkephalin releaser/degradation stabilizer) | ||
}}<noinclude> | }}<noinclude> | ||
{{Documentation}} | {{Documentation}} | ||
</noinclude> | </noinclude> | ||
Latest revision as of 19:56, 8 March 2025
