Template:Cell wall disruptive antibiotics - WikiMD's medical encyclopedia

β-lactams
(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases)

β-lactamase sensitive (1st generation)	- Benzylpenicillin (G)^# - Benzathine benzylpenicillin^# - Procaine benzylpenicillin^# - Phenoxymethylpenicillin (V)^# - Propicillin^‡ - Pheneticillin^‡ - Azidocillin^‡ - Clometocillin^‡ - Penamecillin^‡
β-lactamase resistant (2nd generation)	- Cloxacillin^# (Dicloxacillin - Flucloxacillin) - Oxacillin - Nafcillin - Methicillin^‡

Aminopenicillins (3rd generation)	- Amoxicillin^# - Ampicillin^# (Pivampicillin - Hetacillin^‡ - Bacampicillin^‡ - Lenampicillin - Metampicillin^‡ - Talampicillin^‡) - Epicillin^‡
Carboxypenicillins (4th generation)	- Ticarcillin - Carbenicillin^‡ / Carindacillin^‡ - Temocillin^‡
Ureidopenicillins (4th generation)	- Piperacillin - Azlocillin^‡ - Mezlocillin^‡
Other	- Mecillinam (Pivmecillinam) - Sulbenicillin^‡

- Carbapenems (Ertapenem

1st generation	- Cefazolin^# - Cefalexin ^# - Cefadroxil - Cefapirin - Cefazedone^‡ - Cefazaflur^‡ - Cefradine^‡ - Cefroxadine^‡ - Ceftezole^‡ - Cefaloglycin^‡ - Cefacetrile^‡ - Cefalonium^‡ - Cefaloridine^‡ - Cefalotin - Cefatrizine^‡
2nd generation	- Cefaclor - Cefprozil - Cefuroxime - Cefuroxime axetil - Cefamandole^‡ - Cefonicid^‡ - Ceforanide^‡ - Cefuzonam^‡ - Cephamycin (Cefoxitin - Cefotetan - Cefminox^‡ - Cefbuperazone^‡ - Cefmetazole^‡) - Carbacephem (Loracarbef^‡)
3rd generation	- Cefixime^# - Ceftriaxone^# - Cefotaxime^# - Antipseudomonal (Ceftazidime^# - Cefoperazone) - Cefdinir - Cefcapene - Cefdaloxime - Ceftizoxime - Cefmenoxime - Cefpiramide - Cefpodoxime - Ceftibuten - Cefditoren - Cefotiam^‡ - Cefetamet^‡ - Cefodizime^‡ - Cefpimizole^‡ - Cefsulodin^‡ - Cefteram^‡ - Ceftiolene^‡ - Oxacephem (Flomoxef - Latamoxef^‡)
4th generation	- Cefepime - Cefozopran^‡ - Cefpirome - Cefquinome^‡
5th generation	- Ceftaroline fosamil - Ceftolozane - Ceftobiprole

Lipopeptides	- Insert into bacterial cell wall causing perforation and depolarization: Daptomycin - Surfactin
Other	- Inhibits PG elongation and crosslinking: Ramoplanin^§

Intracellular

- Inhibit PG subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)

Other

- Hydrolyze NAM-NAG