Pentoxifylline
Information about Pentoxifylline
Pentoxifylline is a xanthine derivative that decreases the viscosity of blood and is used to treat symptoms of intermittent claudication due to peripheral vascular disease.
Liver safety of Pentoxifylline
Pentoxifylline has not been associated with serum enzyme elevations during therapy, but in several isolated case reports has been linked to clinically apparent liver injury.
Mechanism of action of Pentoxifylline
Pentoxifylline (pen" tox if' i lin) is a small molecular weight methyl derivative of xanthine that appears to act by improving red blood cell deformability, thus reducing blood viscosity as well as decreasing platelet aggregation and thrombus formation.
Current indications are limited to symptomatic therapy of intermittent claudication. Several prospective controlled trials have shown that pentoxifylline decreases symptoms of intermittent claudication, although its overall effects appear to be modest. Pentoxifylline is a xanthine and also acts as a nonselective inhibitor of phosphodiesterases, which causes an increase in intracellular cyclic AMP and decreased synthesis of tumor necrosis factor alpha and leukotrienes. These antiinflammatory effects have led to its evaluation in several inflammatory liver diseases such as acute and chronic alcoholic hepatitis, nonalcoholic steatohepatitis (NASH), and autoimmune liver diseases.
FDA approval information for Pentoxifylline
Pentoxifylline was approved in the United States in 1984 after it had been used extensively in other countries for more than a decade.
Dosage and administration for Pentoxifylline
Pentoxifylline is available by prescription in extended release tablets of 400 mg in several generic forms and under the brand names Trental and Pentoxil. The recommended dose is 400 mg three times daily with meals.
Side effects of Pentoxifylline
Side effects are not uncommon and can include flushing, abdominal discomfort, diarrhea, dyspepsia, nausea, headache, dizziness and blurred vision. Patients with intolerance to xanthines such as caffeine or theophylline may have similar symptoms with pentoxifylline. Beta-2 Adrenergic Agonists
Albuterol, Bitolterol, Formoterol, Metaproterenol, Pirbuterol, Salbutamol, Salmeterol, Terbutaline
Leukotriene Receptor Antagonists
Benralizumab, Mepolizumab, Omalizumab, Reslizumab
Peripheral vasodilators (C04) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Purine receptor modulators | ||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
See also: Receptor/signaling modulators
|
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Kondreddy Naveen