L-β,γ-Me-ATP

From WikiMD's medical encyclopedia


Overview

L-β,γ-Me-ATP is a synthetic analogue of adenosine triphosphate (ATP), which is primarily used in scientific research to study the function of purinergic receptors. This compound is particularly useful in the investigation of P2X receptors, a family of ligand-gated ion channels activated by ATP.

Chemical Structure

L-β,γ-Me-ATP is a modified form of ATP where a methyl group is introduced at the β,γ position of the phosphate chain. This modification alters the molecule's interaction with purinergic receptors, making it a valuable tool for distinguishing between different receptor subtypes.

Mechanism of Action

L-β,γ-Me-ATP acts as an agonist or antagonist at various purinergic receptors, depending on the receptor subtype and the experimental conditions. It is known to preferentially activate certain P2X receptors, such as P2X1 and P2X3, while having less effect on others. This selectivity is crucial for dissecting the roles of different P2X receptor subtypes in physiological and pathological processes.

Applications in Research

L-β,γ-Me-ATP is widely used in pharmacological studies to:

Experimental Considerations

When using L-β,γ-Me-ATP in experiments, researchers must consider factors such as:

  • Concentration: The effective concentration of L-β,γ-Me-ATP can vary depending on the receptor subtype and the experimental setup.
  • Duration of exposure: Prolonged exposure to L-β,γ-Me-ATP can lead to receptor desensitization, affecting the outcome of the experiment.
  • Species differences: The response to L-β,γ-Me-ATP can differ between species, necessitating careful interpretation of results.

Safety and Handling

As with all chemical reagents, proper safety protocols should be followed when handling L-β,γ-Me-ATP. This includes wearing appropriate personal protective equipment and working in a well-ventilated area.

Also see

References



Template:Purinergic system

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP-1 injections from $125.

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:

NYC weight loss doctor appointments

Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.

Linkedin_Shiny_Icon Facebook_Shiny_Icon YouTube_icon_(2011-2013) Google plus


Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD