Membrane transport protein

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Membrane Transport Protein

Diagram of the sodium-potassium pump, an example of an active transport protein.

A membrane transport protein (or transporter) is a type of protein that facilitates the movement of substances across a cell membrane. These proteins are essential for maintaining the proper function of cells by regulating the internal environment and allowing the import and export of various molecules.

Types of Membrane Transport Proteins

Membrane transport proteins can be classified into several types based on their mechanism of action and the direction of transport.

Channel Proteins

Channel proteins form pores in the membrane, allowing specific molecules or ions to pass through by facilitated diffusion. These channels can be gated, opening or closing in response to stimuli such as voltage changes or ligand binding.

Carrier Proteins

Carrier proteins bind to the substance they transport and undergo a conformational change to move the substance across the membrane. They can function via passive or active transport mechanisms.

Uniporters

Illustration of a uniporter, which transports a single type of molecule.

Uniporters transport a single type of molecule down its concentration gradient. This process is a form of facilitated diffusion.

Symporters

Illustration of a symporter, which transports two different molecules in the same direction.

Symporters move two or more different molecules in the same direction across the membrane. This process often involves coupling the transport of one molecule with the movement of another, typically using the energy from the concentration gradient of one of the molecules.

Antiporters

Illustration of an antiporter, which transports two different molecules in opposite directions.

Antiporters transport two or more different molecules in opposite directions. This type of transport is often used to exchange ions across the membrane, such as in the sodium-potassium pump.

Mechanisms of Transport

Passive Transport

Passive transport does not require energy and occurs when molecules move down their concentration gradient. This includes simple diffusion, facilitated diffusion through channel proteins, and transport via uniporters.

Active Transport

Active transport requires energy, usually in the form of ATP, to move molecules against their concentration gradient. This includes primary active transport, such as the sodium-potassium pump, and secondary active transport, which uses the energy from the movement of one molecule to drive the transport of another.

Diagram illustrating facilitated diffusion through a cell membrane.

Functions of Membrane Transport Proteins

Membrane transport proteins are crucial for various cellular processes, including:

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Contributors: Prab R. Tumpati, MD