NF-449

NF-449

NF-449 is a chemical compound known for its role as a selective antagonist of the P2X1 receptor, a subtype of the P2X receptor family. These receptors are ligand-gated ion channels that are activated by the binding of extracellular adenosine triphosphate (ATP). NF-449 is particularly noted for its high selectivity towards the P2X1 receptor, making it a valuable tool in the study of purinergic signaling.

Chemical Structure and Properties

NF-449 is a suramin analogue, characterized by its complex structure that includes multiple sulfonate groups. The presence of these groups is crucial for its interaction with the P2X1 receptor, contributing to its high affinity and selectivity.

Molecular Formula

The molecular formula of NF-449 is C28H24N6O8S6.

Molecular Weight

The molecular weight of NF-449 is approximately 740.88 g/mol.

Mechanism of Action

NF-449 functions as a competitive antagonist at the P2X1 receptor. By binding to the receptor, it prevents the action of ATP, thereby inhibiting the receptor's ion channel activity. This blockade of the P2X1 receptor can modulate various physiological processes, including platelet aggregation, smooth muscle contraction, and neurotransmission.

Applications in Research

Due to its specificity, NF-449 is widely used in research to study the physiological and pathological roles of P2X1 receptors. It has been instrumental in elucidating the role of these receptors in cardiovascular function, pain perception, and immune responses.

Cardiovascular Research

In cardiovascular studies, NF-449 has been used to investigate the role of P2X1 receptors in vasoconstriction and blood pressure regulation.

Pain and Sensory Research

NF-449 has also been employed in studies exploring the involvement of P2X1 receptors in nociception and sensory neuron signaling.

Safety and Handling

As with many research chemicals, NF-449 should be handled with care. Appropriate safety measures, including the use of personal protective equipment, should be employed when working with this compound.

Also see

• P2X receptor
• Adenosine triphosphate
• Suramin
• Ion channel

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