Renin inhibitor
Renin inhibitors are a type of medication that are used to treat hypertension. They work by reducing the amount of renin produced by the body, which in turn lowers blood pressure.
Mechanism of Action
Renin inhibitors work by directly inhibiting the activity of renin, an enzyme that plays a crucial role in the Renin-Angiotensin-Aldosterone System. Renin is responsible for the conversion of angiotensinogen to angiotensin I, which is then converted to angiotensin II by the action of ACE. Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone, which promotes sodium and water retention. By inhibiting the activity of renin, these drugs prevent the formation of angiotensin II, resulting in vasodilation and a decrease in blood pressure.
Uses
Renin inhibitors are primarily used in the treatment of hypertension. They may be used alone or in combination with other antihypertensive agents. They are also used in the treatment of heart failure and chronic kidney disease.
Side Effects
Like all medications, renin inhibitors can cause side effects. These may include dizziness, fatigue, and diarrhea. In rare cases, they may cause a persistent dry cough or angioedema.
Examples
The most commonly used renin inhibitor is aliskiren. Other examples include remikiren and enalkiren.
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