Template:Cell wall disruptive antibiotics: Difference between revisions
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| name = Cell wall disruptive antibiotics | |||
| title = [[Antibiotics|Antibacterials]] active on the [[cell wall]] and [[cell envelope antibiotic|envelope]] ([[ATC code J01#J01C|J01C]]-[[ATC code J01#J01D|J01D]]) | |||
| state = {{{state<includeonly>|autocollapse</includeonly>}}} | |||
</ | | listclass = hlist | ||
< | | group1 = [[Beta-lactam antibiotics|β-lactams]]<br /><small>{{nobold|(inhibit synthesis<br />of peptidoglycan<br />layer of bacterial<br />cell wall by binding<br />to and inhibiting<br />[[Penicillin-binding proteins|PBPs]], a group of<br />[[DD-Transpeptidase|<small>D</small>-alanyl-<small>D</small>-alanine<br />transpeptidases]])}}</small> | ||
< | | list1 = {{Navbox|child | ||
< | |||
| group1 = [[Penicillin]]s ([[Penam]]s) | |||
| list1 = {{Navbox|child | |||
[[ | |||
| group1 = [[List of β-lactam antibiotics#Narrow-spectrum|Narrow<br/>spectrum]] | |||
| list1 = {{Navbox|child | |||
| group1 = [[List of β-lactam antibiotics#Narrow-spectrum|β-lactamase sensitive]]<br/>(1st generation) | |||
[[ | | list1 = | ||
- [[Benzylpenicillin|Benzylpenicillin (G)]]<sup>#</sup> | |||
- [[Benzathine benzylpenicillin]]<sup>#</sup> | |||
- [[Procaine benzylpenicillin]]<sup>#</sup> | |||
- [[Phenoxymethylpenicillin|Phenoxymethylpenicillin (V)]]<sup>#</sup> | |||
- [[Propicillin]]<sup>‡</sup> | |||
- [[Pheneticillin]]<sup>‡</sup> | |||
- [[Azidocillin]]<sup>‡</sup> | |||
- [[Clometocillin]]<sup>‡</sup> | |||
- [[Penamecillin]]<sup>‡</sup> | |||
| group2 = [[List of β-lactam antibiotics#β-lactamase-resistant|β-lactamase resistant]]<br/>(2nd generation) | |||
[[ | | list2 = | ||
- [[Cloxacillin]]<sup>#</sup> ([[Dicloxacillin]] | |||
- [[Flucloxacillin]]) | |||
- [[Oxacillin]] | |||
- [[Nafcillin]] | |||
- [[Methicillin]]<sup>‡</sup> | |||
}} | |||
| group2 = [[Extended-spectrum penicillin|Extended<br/>spectrum]] | |||
[[ | | list2 = {{Navbox|child | ||
< | | group1 = [[Aminopenicillin]]s (3rd generation) | ||
[[ | | list1 = | ||
- [[Amoxicillin]]<sup>#</sup> | |||
- [[Ampicillin]]<sup>#</sup> ([[Pivampicillin]] | |||
- [[Hetacillin]]<sup>‡</sup> | |||
- [[Bacampicillin]]<sup>‡</sup> | |||
- [[Lenampicillin]] | |||
- [[Metampicillin]]<sup>‡</sup> | |||
- [[Talampicillin]]<sup>‡</sup>) | |||
- [[Epicillin]]<sup>‡</sup> | |||
< | | group2 = [[Carboxypenicillin]]s (4th generation) | ||
| list2 = | |||
- [[Ticarcillin]] | |||
- [[Carbenicillin]]<sup>‡</sup> / [[Carindacillin]]<sup>‡</sup> | |||
- [[Temocillin]]<sup>‡</sup> | |||
| group3 = [[Ureidopenicillin]]s (4th generation) | |||
[[ | | list3 = | ||
- [[Piperacillin]] | |||
- [[Azlocillin]]<sup>‡</sup> | |||
- [[Mezlocillin]]<sup>‡</sup> | |||
< | | group4 = Other | ||
| list4 = | |||
- [[Mecillinam]] ([[Pivmecillinam]]) | |||
- [[Sulbenicillin]]<sup>‡</sup> | |||
}} | |||
}} | |||
| group2 = [[Carbapenem]]s / [[Penem]]s | |||
[[ | | list2 = | ||
- Carbapenems ([[Ertapenem]] | |||
- [[Antipseudomonal]] ([[Doripenem]] | |||
- [[Imipenem]] | |||
- [[Meropenem]]) | |||
- [[Biapenem]]<sup>‡</sup> | |||
- [[Panipenem]]) | |||
- Penems ([[Faropenem]] | |||
- [[Ritipenem]]<sup>§</sup> | |||
- [[Sulopenem]]) | |||
| group3 = [[Cephem]]s<br/>[[Cephalosporin]]s<br/>[[Cephamycin]]s<br/>[[Carbacephem]]s | |||
[[ | | list3 = {{Navbox|child | ||
< | | group1 = [[Cephalosporin#First generation|1st generation]] | ||
[[ | | list1 = | ||
- [[Cefazolin]]<sup>#</sup> | |||
- [[Cefalexin]] <sup>#</sup> | |||
- [[Cefadroxil]] | |||
- [[Cefapirin]] | |||
- [[Cefazedone]]<sup>‡</sup> | |||
- [[Cefazaflur]]<sup>‡</sup> | |||
- [[Cefradine]]<sup>‡</sup> | |||
- [[Cefroxadine]]<sup>‡</sup> | |||
- [[Ceftezole]]<sup>‡</sup> | |||
- [[Cefaloglycin]]<sup>‡</sup> | |||
- [[Cefacetrile]]<sup>‡</sup> | |||
- [[Cefalonium]]<sup>‡</sup> | |||
- [[Cefaloridine]]<sup>‡</sup> | |||
- [[Cefalotin]] | |||
- [[Cefatrizine]]<sup>‡</sup> | |||
< | | group2 = [[Cephalosporin#Second generation|2nd generation]] | ||
[[ | | list2 = | ||
- [[Cefaclor]] | |||
- [[Cefprozil]] | |||
- [[Cefuroxime]] | |||
- [[Cefuroxime axetil]] | |||
- [[Cefamandole]]<sup>‡</sup> | |||
- [[Cefonicid]]<sup>‡</sup> | |||
- [[Ceforanide]]<sup>‡</sup> | |||
- [[Cefuzonam]]<sup>‡</sup> | |||
- [[Cephamycin]] ([[Cefoxitin]] | |||
- [[Cefotetan]] | |||
- [[Cefminox]]<sup>‡</sup> | |||
- [[Cefbuperazone]]<sup>‡</sup> | |||
- [[Cefmetazole]]<sup>‡</sup>) | |||
- [[Carbacephem]] ([[Loracarbef]]<sup>‡</sup>) | |||
< | | group3 = [[Cephalosporin#Third generation|3rd generation]] | ||
[[ | | list3 = | ||
- [[Cefixime]]<sup>#</sup> | |||
- [[Ceftriaxone]]<sup>#</sup> | |||
- [[Cefotaxime]]<sup>#</sup> | |||
- Antipseudomonal ([[Ceftazidime]]<sup>#</sup> | |||
- [[Cefoperazone]]) | |||
- [[Cefdinir]] | |||
- [[Cefcapene]] | |||
- [[Cefdaloxime]] | |||
- [[Ceftizoxime]] | |||
- [[Cefmenoxime]] | |||
- [[Cefpiramide]] | |||
- [[Cefpodoxime]] | |||
- [[Ceftibuten]] | |||
- [[Cefditoren]] | |||
- [[Cefotiam]]<sup>‡</sup> | |||
- [[Cefetamet]]<sup>‡</sup> | |||
- [[Cefodizime]]<sup>‡</sup> | |||
- [[Cefpimizole]]<sup>‡</sup> | |||
- [[Cefsulodin]]<sup>‡</sup> | |||
- [[Cefteram]]<sup>‡</sup> | |||
- [[Ceftiolene]]<sup>‡</sup> | |||
- [[Oxacephem]] ([[Flomoxef]] | |||
- [[Latamoxef]]<sup>‡</sup>) | |||
< | | group4 = [[Cephalosporin#Fourth generation|4th generation]] | ||
[[ | | list4 = | ||
- [[Cefepime]] | |||
- [[Cefozopran]]<sup>‡</sup> | |||
- [[Cefpirome]] | |||
- [[Cefquinome]]<sup>‡</sup> | |||
| group5 = [[Cephalosporin#Fifth generation|5th generation]] | |||
| list5 = | |||
- [[Ceftaroline fosamil]] | |||
- [[Ceftolozane]] | |||
- [[Ceftobiprole]] | |||
| group6 = [[Siderophore]] | |||
[[ | | list6 = | ||
- [[Cefiderocol]]<sup>#</sup> | |||
| group7 = [[Veterinary medicine|Veterinary]] | |||
| list7 = | |||
- [[Ceftiofur]] | |||
- [[Cefquinome]] | |||
- [[Cefovecin]] | |||
}} | |||
< | | group4 = [[Monobactam]]s | ||
| list4 = | |||
- [[Aztreonam]] | |||
- [[Tigemonam]]<sup>‡</sup> | |||
- [[Carumonam]]<sup>‡</sup> | |||
- [[Nocardicin A]]<sup>‡</sup> | |||
| group5 = [[β-Lactamase inhibitor|β-lactamase inhibitors]] | |||
[[ | | list5 = | ||
- [[Penam]] ([[Sulbactam]] | |||
- [[Tazobactam]]) | |||
- [[Clavam]] ([[Clavulanic acid]]) | |||
- non-β-lactam ([[Avibactam]] | |||
- [[Durlobactam]] | |||
- [[Relebactam]] | |||
- [[Vaborbactam]]) | |||
</ | | group6 = Combinations | ||
</ | | list6 = | ||
- [[Amoxicillin/clavulanic acid]]<sup>#</sup> | |||
- [[Ampicillin/flucloxacillin]] | |||
- [[Ampicillin/sulbactam]] ([[Sultamicillin]]) | |||
- [[Aztreonam/avibactam]] | |||
- [[Benzathine benzylpenicillin/procaine benzylpenicillin]] | |||
- [[Cefepime/enmetazobactam]] | |||
- [[Cefoperazone/sulbactam]] | |||
- [[Ceftazidime/avibactam]] | |||
- [[Ceftolozane/tazobactam]] | |||
- [[Imipenem/cilastatin]]<sup>#</sup> | |||
- [[Imipenem/cilastatin/relebactam]] | |||
- [[Meropenem/vaborbactam]] | |||
- [[Panipenem/betamipron]] | |||
- [[Piperacillin/tazobactam]] | |||
- [[Sulbactam/durlobactam]] | |||
- [[Sulopenem/probenecid]] | |||
- [[Ticarcillin/clavulanic acid]] | |||
}} | |||
| group2 = [[Polypeptide antibiotic|Polypeptides]] | |||
| list2 = {{Navbox|child | |||
[[ | |||
| group1 = [[Lipopeptide|Lipopeptides]] | |||
| list1 = | |||
- Insert into bacterial cell wall causing perforation and depolarization: [[Daptomycin]] | |||
- [[Surfactin]] | |||
[[ | |||
</ | | group2 = Other | ||
| list2 = | |||
- Inhibits PG elongation and crosslinking: [[Ramoplanin]]<sup>§</sup> | |||
}} | |||
| group3 = Intracellular | |||
| list3 = | |||
- Inhibit [[peptidoglycan|PG]] subunit synthesis and transport: [[N-Acetylmuramic acid|NAM]] synthesis inhibition ([[Fosfomycin]]) | |||
- [[D-alanine—D-alanine ligase|DADAL]]/[[Alanine racemase|AR]] inhibitors ([[Cycloserine]]) | |||
- [[bactoprenol]] inhibitors ([[Bacitracin]]) | |||
| group4 = Other | |||
< | | list4 = | ||
</ | - Hydrolyze NAM-NAG | ||
- - [[lysozyme]] | |||
- [[Tyrothricin]] | |||
- - [[Gramicidin]] | |||
- - [[Tyrocidine]] | |||
- [[Isoniazid]]<sup>#</sup> | |||
- [[Teixobactin]] | |||
<noinclude> | | belowstyle = padding: 0px; | ||
{{ | | below = {{PharmNavFootnote}} | ||
}}<noinclude> | |||
{{collapsible option}} | |||
[[Category:Drug templates by ATC]] | [[Category:Drug templates by ATC]] | ||
[[Category:Bactericides| | [[Category:Bactericides|- ]] | ||
</noinclude> | </noinclude> | ||
