List of autoimmune diseases

This list of autoimmune diseases is categorized by organ and tissue type to help locate diseases that may be similar.

Autoimmune diseases qualifiers

Overview of the qualifiers for the list.

Other Qualifiers
A	"Accepted" in prior version of this table
C	A disease, regarded as autoimmune, that is often found in individuals with another autoimmune condition. This designation is given to diseases that are classified by Rose and Bona as having "circumstantial" evidence of autoimmune etiology. Diseases in this list with a "C" are, therefore, actual autoimmune diseases, rather than comorbid symptoms, which appear after this list.
E	Disease is an autoimmune response triggered by a specific environmental factor
F	Disease is only caused by autoimmunity in only a fraction of those who suffer from it
I	Described as an autoinflammatory disease
L	Evidence to indicate autoimmunity is extremely limited or circumstantial
M	Disease appears under Autoimmune Diseases in MeSH
N	Not listed in prior version of this table
R	Disease appeared in prior version but has been renamed. In renaming, precedence has been given to scientific names over those based on discoverers.
S	"Suspected" in the prior version of this table
T	Disease has a known trigger, such as viral infection, vaccination, or injury
X	An extremely rare disease, which would suggest limited opportunity to study it and conclusively determine whether it is caused by autoimmunity
Y	Listed in the prior version of this table with "Accepted/Suspected" left blank

Autoimmune diseases

This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

Major organs

Organ/Tissue Type Disease Name	Level of Acceptance for Autoimmunity	Hypersensitivity (I,II,III,IV)	ICD-9 Codes	Notes/Autoantibodies/Synonyms/Rare Variants
Heart
Myocarditis<ref>, Unresolved issues in theories of autoimmune disease using myocarditis as a framework, Journal of Theoretical Biology, Vol. 375, pp. 101–23, DOI: 10.1016/j.jtbi.2014.11.022, PMID: 25484004, PMC: 4417457,</ref><ref name="The autoimmune diseases">, The autoimmune diseases, Fifth edition, [S.l.]:Academic Press, ISBN 978-0-12-384929-8,</ref>||Moderate, F, R, A||||391.2422429.0||Synonyms: Autoimmune myocarditis, Autoimmune cardiomyopathy, Coxsackie myocarditis
Postmyocardial infarction syndrome<ref name="The autoimmune diseases"/>	Limited, R, Y		411.0	Autoantibodies: Myocardial neo-antigens formed as a result of the MI. Synonym: Dressler's syndrome
Postpericardiotomy syndrome	Limited, N		429.4
Subacute bacterial endocarditis (SBE)<ref name="pmid9402102"> </ref>||Limited, Y||III||421.0||Autoantibodies: essential mixed cryoglobulinemia.
Kidney
Anti-Glomerular Basement Membrane nephritis<ref name = "Mesh"/>	Moderate, R, M, A	II	446.21	Autoantibodies: Anti-Basement Membrane Collagen Type IV Protein. Synonyms: Goodpastures Syndrome, Glomerulonephritis Type 1
Interstitial cystitis<ref>, [Interstitial cystitis=autoimmune cyatitis? Interstitial as a participating disease in lupus erythematosus], Zeitschrift für Urologie und Nephrologie, 1975, Vol. 68(Issue: 9), pp. 633–9, PMID: 1227191,</ref>||Limited, S||||595.1||Mast cells.
Lupus nephritis	Comorbidity, N		583.81	A comorbidity of Systemic Lupus Erythematosus.
Liver
Autoimmune hepatitis<ref name="pmid18528935">, Autoimmune liver serology: Current diagnostic and clinical challenges, World Journal of Gastroenterology, Vol. 14(Issue: 21), pp. 3374–3387, DOI: 10.3748/wjg.14.3374, PMID: 18528935, PMC: 2716592, Full text,</ref><ref name="urlautoimmune hepatitis"> autoimmune hepatitis(link). '. </ref><ref name="urlMedscape & eMedicine Log In"> Medscape & eMedicine Log In(link). '. </ref>||Moderate, A||cell-mediated||571.42||Autoantibodies: ANA and SMA, LKM-1, LKM-2 or LKM-3; antibodies against soluble liver antigen (anti-SLA, anti-LP) no autoantibodies detected (~20%)[citation needed]. Synonym: Lupoid hepatitis
Primary biliary cholangitis (PBC)<ref name="titlePrimary Biliary Cirrhosis: Fatty Liver, Cirrhosis, and Related Disorders: Merck Manual Home Health Handbook"> Primary Biliary Cirrhosis: Fatty Liver, Cirrhosis, and Related Disorders: Merck Manual Home Health Handbook(link). '. </ref><ref name="Franceschini2005" /><ref name="Franceschini2005a" /><ref name="Goeb2007" />||Moderate, A||||571.6||Autoantibodies: Anti-p62, Anti-sp100, Anti-Mitochondrial(M2), Anti-Ro aka SSA. Note that Sjogren's is classified in some places (e.g. MeSH) as rheumatoid disease, but there is no published evidence to support that classification.
Primary sclerosing cholangitis	Limited, Y		576.1	Possible overlap with primary biliary cirrhosis. Autoantibodies: HLA-DR52a.
Lung
Antisynthetase syndrome	Limited, Y		279.49
Skin
Alopecia Areata<ref>American Academy of Dermatology, Archived copy(link). {{{website}}}. </ref><ref>HtmlThe University of Texas MD Anderson Cancer Center, http://www.mdanderson.org/patient-and-cancer-information/cancer-information/cancer-types/alopecia-areata/index.html</ref>||Moderate, A||||704.01||Autoantibodies: T-cells. Synonyms: Alopecia areata - Patchy, Totalis, Universalis
Autoimmune Angioedema<ref name="Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A 2002 iii8">, Ankylosing spondylitis: an overview, Annals of the Rheumatic Diseases, 2002, Vol. 61(Issue: 3), pp. iii8–18, DOI: 10.1136/ard.61.suppl_3.iii8, PMID: 12381506, PMC: 1766729,</ref>||Limited, F, N||||277.6 995.1||
Autoimmune progesterone dermatitis	Limited, X, A		279.49
Autoimmune urticaria<ref>, Functional | assessment of pathogenic IgG subclass in chronic autoimmune urticaria, The Journal of Allergy and Clinical Immunology, 2004, Vol. 115(Issue: 4), pp. 815–21, DOI: 10.1016/j.jaci.2004.12.1120, PMID: 15806004,</ref><ref>, Chronic autoimmune urticaria : Where we stand ?, Indian Journal of Dermatology, Vol. 54(Issue: 3), pp. 269–74, DOI: 10.4103/0019-5154.55640, PMID: 20161862, PMC: 2810697,</ref>||Comorbidity, A||||708||
Bullous pemphigoid<ref name="urlAutoimmune Disorders: Immune Disorders: Merck Manual Home Edition"> Autoimmune Disorders: Immune Disorders: Merck Manual Home Health Handbook(link). '. </ref> ||Moderate, Y||||694.5||Autoantibodies: IgG autoantibodies targeting the type XVII collagen component of hemidesmosomes.
Cicatricial pemphigoid	Limited, R, X, Y		694.61	precipitates C3. Autoantibodies: anti-BP-1, anti-BP-2. Synonyms: Benign Mucosal Pemphigoid, Ocular cicatricial pemphigoid
Dermatitis herpetiformis<ref name="Kumar12-6"/>	Moderate, C, Y		694.0	Autoantibodies: IgA Eosinophilia; anti-epidermal transglutaminase antibodies.
Discoid lupus erythematosus<ref>, Detection of Type 1 Cytokines in Discoid Lupus Erythematosus, Archives of Dermatology, 2000, Vol. 136(Issue: 12), pp. 1497–1501, DOI: 10.1001/archderm.136.12.1497, PMID: 11115160,</ref>||Limited, Y||III||695.4||IL-2 and IFN-gamma.
Epidermolysis bullosa acquisita	Moderate, Y		694.8	COL7A1.
Erythema nodosum	Limited, F, Y		695.2
Gestational pemphigoid	Limited, R, Y		646.8	Autoantibodies: IgG and C3 misdirected antibodies intended to protect the placenta.
Hidradenitis suppurativa<ref> Clinical Trial: Etanercept in Hidradenitis Suppurativa(link). '. </ref>||Limited, C, S||||705.83||
Lichen planus	Limited, Y		697.0
Lichen sclerosus	Limited, C, Y		701.0
Linear IgA disease (LAD)<ref name="Andrews">James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.</ref>	Moderate, Y		646.8
Morphea<ref name="pmid15561734">, Localized scleroderma is an autoimmune disorder, Rheumatology, 2005, Vol. 44(Issue: 3), pp. 274–9, DOI: 10.1093/rheumatology/keh487, PMID: 15561734,</ref> ||Limited, C, S||||701.0||
Pemphigus vulgaris<ref name = "Mesh"/><ref name="Kumar12-6"/>	Moderate, M, A	II	694.4	Autoantibodies: Anti-Desmoglein 3 eosinophilia.
Pityriasis lichenoides et varioliformis acuta	Limited, C		696.2
Mucha-Habermann disease	Limited, C, Y		696.2	T-cells. Synonyms: Pityriasis lichenoides, varioliformis acuta
Psoriasis<ref>National Psoriasis Foundation, http://www.psoriasis.org/home/learn01.php</ref>	Moderate, A	IV?	696	CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB.
Systemic scleroderma<ref name="pmid15561734"/><ref name=JimenezDerk>, Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis, Annals of Internal Medicine, 2004, Vol. 140(Issue: 1), pp. 37–50, DOI: 10.7326/0003-4819-140-2-200401200-00013, PMID: 14706971,</ref> ||Limited, R, S||||710.1||COL1A2 and TGF-β1. Autoantibodies: Anti-nuclear antibodies, anti-centromere and anti-scl70/anti-topoisomerase antibodies. Synonyms: Diffuse cutaneous systemic sclerosis, Systemic sclerosis, Scleroderma
Vitiligo<ref> Questions and Answers about Vitiligo(link). '. </ref><ref> A New Gene Linked to Vitiligo and Susceptibility to Autoimmune Disorders - Journal Watch Dermatology(link). {{{website}}}. </ref>||Limited, C, S||||709.01||NALP-1 RERE, PTPN22, LPP, IL2RA, GZMB, UBASH3A and C1QTNF6.

Glands

Organ/Tissue Type Disease Name	Level of Acceptance for Autoimmunity	Hypersensitivity (I,II,III,IV)	ICD-9 Codes	Notes/Autoantibodies/Synonyms/Rare Variants
Endocrine
Adrenal Gland
Addison's disease<ref name="Mesh">Autoimmune+Diseases at the US National Library of Medicine Medical Subject Headings (MeSH) </ref>||Moderate, F, Y||||255 ||Autoantibodies: 21 hydroxylase.
Multi-Glandular
Autoimmune polyendocrine syndrome (APS) type 1	Moderate, A	Unknown or multiple	258.1	Synonyms: Whitaker's Syndrome, Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), Addisons Disease, Polyglandular Autoimmune Syndrome 1 (PGAS-1).
Autoimmune polyendocrine syndrome (APS) type 2<ref name="pmid10664529">, Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III, European Journal of Endocrinology, Vol. 142(Issue: 2), pp. 187–94, DOI: 10.1530/eje.0.1420187, PMID: 10664529, Full text,</ref>||Moderate, A||||258.1||DQ2, DQ8 and DRB1*0404. Autoantibodies: anti-21 hydroxylase, anti-17 hydroxylase. Synonyms: Schmidt syndrome, Polyglandular Autoimmune Syndrome 2 (PGAS-2).
Autoimmune polyendocrine syndrome (APS) type 3	Moderate, A		258.1	Synonym: Polyglandular Autoimmune Syndrome 3 (PGAS-3).
Pancreas
Autoimmune pancreatitis (AIP)	Moderate, A		577.1	Autoantibodies: ANA, anti-lactoferrin antibodies, anti-carbonic anhydrase antibodies, rheumatoid factor.
Diabetes mellitus type 1<ref name = "Mesh"/>	Moderate, A	IV	250.01	HLA-DR3, HLA-DR4. Autoantibodies: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), insulinoma-associated autoantibodies (IA-2), anti-insulin antibodies.
Thyroid Gland
Autoimmune thyroiditis	Strong, A	IV	245.8	HLADR5, CTLA-4. Autoantibodies: Antibodies against thyroid peroxidase and/or thyroglobulin. Synonyms: Chronic lymphocytic thyroiditis, Hashimoto's thyroiditis.
Ord's thyroiditis	Moderate, Y		245.8
Graves' disease<ref name = "Mesh"/>	Moderate, M, A	II	242.0	Autoantibodies: Thyroid autoantibodies (TSHR-Ab) that activate the TSH-receptor (TSHR).
Exocrine
Reproductive Organs
Autoimmune Oophoritis	Moderate, N		614.2
Endometriosis<ref>, Is endometriosis an autoimmune disease?, Obstetrics and Gynecology, 1987, Vol. 70(Issue: 1), pp. 115–22, PMID: 3110710,</ref>||Limited, S||||617.0||
Autoimmune orchitis	Limited, N		604.0
Salivary Glands
Sjogren's syndrome<ref name = "Mesh"/><ref name="Franceschini2005" /><ref name="Franceschini2005a" /><ref name="Goeb2007" />	Moderate, A		710.2	Autoantibodies: Anti-Ro (often present also in Systemic Lupus Erythematosus).

Digestive system

Organ/Tissue Type Disease Name	Level of Acceptance for Autoimmunity	Hypersensitivity (I,II,III,IV)	ICD-9 Codes	Notes/Autoantibodies/Synonyms/Rare Variants
Digestive System
Autoimmune enteropathy	Moderate, X, Y		{{{1}}}
Coeliac disease<ref name="urlCeliac Disease"> Celiac Disease(link). '. </ref><ref name="pmid16234635">Meize-Grochowski R, Celiac disease: a multisystem autoimmune disorder, Gastroenterology Nursing, 2005, Vol. 28(Issue: 5), pp. 394–402; quiz 403–4, DOI: 10.1097/00001610-200509000-00005, PMID: 16234635, Full text,</ref><ref name="pmid16214317">, Is celiac disease an autoimmune disorder?, Current Opinion in Immunology, Vol. 17(Issue: 6), pp. 595–600, DOI: 10.1016/j.coi.2005.09.015, PMID: 16214317,</ref>||Moderate, A,E||IV??||579.0||HLA-DQ8 and DQ2.5. Autoantibodies: Anti-tissue transglutaminase antibodies, anti-endomysial IgA, anti-gliadin IgA.
Crohn's disease<ref>, Innate immunity in Crohn's disease: the reverse side of the medal., Journal of Clinical Gastroenterology, Vol. 42 Suppl 3 Pt 1, pp. S144–7, DOI: 10.1097/MCG.0b013e3181662c90, PMID: 18806708,</ref>||Moderate, Y||IV||555||Innate immunity; Th17; Th1; ATG16L1; CARD15; XBP1.
Microscopic colitis	Limited, S		558.9
Ulcerative colitis<ref name="Mesh" />	Limited, A	IV	556

Tissue

Organ/Tissue Type Disease Name	Level of Acceptance for Autoimmunity	Hypersensitivity (I,II,III,IV)	ICD-9 Codes	Notes/Autoantibodies/Synonyms/Rare Variants
Blood
Antiphospholipid syndrome (APS, APLS)<ref name="Mesh"/>	Moderate, M, A		289.81	HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3. Autoantibodies: Anti-cardiolipin; anti-pyruvate dehydrogenase; β2 glycoprotein I; phosphatidylserine; anti-apoH; Annexin A5. Synonym: Hughes syndrome.
Aplastic anemia	Limited, F, Y		284
Autoimmune hemolytic anemia	Moderate, M, A	II	283.0	Complement activation.
Autoimmune lymphoproliferative syndrome	Moderate, A		279.41	TNFRSF6; defective Fas-CD95 apoptosis. Synonym: Canale-Smith syndrome.
Autoimmune neutropenia	Moderate, F, N		288.09
Autoimmune thrombocytopenic purpura<ref name = "Mesh"/>	Moderate, M, R, A		287.31	Autoantibodies: Anti gpIIb-IIIa or 1b-IX. Synonym: Idiopathic Thrombocytopenic Purpura (ITP)
Cold agglutinin disease	Moderate, M, A	II	283.0	Idiopathic or secondary to leukemia or infection. Autoantibodies: IgM. Synonym: Autoimmune hemolytic anemia.
Essential mixed cryoglobulinemia	Limited, C, Y		273.2
Evans syndrome	Moderate, Y		287.32	Syndrome with a combination of hemolytic anemia and thrombocytopenic purpura
Pernicious anemia<ref name="titleMedlinePlus Medical Encyclopedia: Pernicious anemia"> MedlinePlus Medical Encyclopedia: Pernicious anemia(link). {{{website}}}. </ref> ||Moderate, A||II||281.0||Autoantibodies: Anti-parietal cell antibody.
Pure red cell aplasia	Limited, Y		284.81
Thrombocytopenia<ref name=Moake2004>Moake JL, von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura, Seminars in Hematology, 2004, Vol. 41(Issue: 1), pp. 4–14, DOI: 10.1053/j.seminhematol.2003.10.003, PMID: 14727254,</ref><ref>, 348 cases of fetal alloimmune thrombocytopenia, The Lancet, 1989, Vol. 1(Issue: 8634), pp. 363–6, DOI: 10.1016/S0140-6736(89)91733-9, PMID: 2563515,</ref>||Limited, F, Y||II||287.5||Multiple mechanisms. Autoantibodies: Glycoproteins IIb-IIIa or Ib-IX in ITP anti-ADAMTS13 in TTP. and HUS anti-cardiolipin (anti-cardiolipin antibodies) and β2 glycoprotein I in Antiphospholipid syndrome; anti-HPA-1a, anti-HPA-5b, and others in NAIT. Synonyms: Neonatal thrombocytopenia
Connective Tissue, Systemic, and Multi-Organ
Adiposis dolorosa<ref name="pmid17448013">, Dercum's disease (adiposis dolorosa): a report of improvement with infliximab and methotrexate, Journal of the European Academy of Dermatology and Venereology, Vol. 21(Issue: 5), DOI: 10.1111/j.1468-3083.2006.02021.x, PMID: 17448013, Full text,</ref>||Limited, L, S||||272.8||Lipoid tissue. Synonym: Dercum's disease
Adult-onset Still's disease<ref name="pmid12746913">, Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis, Arthritis & Rheumatology, Vol. 48(Issue: 5), pp. 1398–407, DOI: 10.1002/art.10882, PMID: 12746913,</ref>||Moderate, Y||||714.2||Macrophage migration inhibitory factor. Autoantibodies: ANA.
Ankylosing spondylitis<ref name="Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A 2002 iii8"/>	Limited, S		720.0	CD8; HLA-B27.
CREST syndrome	Limited, Y		710.1	Autoantibodies: Anti-centromere antibodies Anti-nuclear antibodies.
Drug-induced lupus	Moderate, Y		710.0	Autoantibodies: Anti-histone antibodies.
Enthesitis-related arthritis<ref name="PMID20606622">Colbert RA, Classification of juvenile spondyloarthritis: Enthesitis-related arthritis and beyond, Nature Reviews Rheumatology, 2010, Vol. 6(Issue: 8), pp. 477–85, DOI: 10.1038/nrrheum.2010.103, PMID: 20606622, PMC: 2994189,</ref><ref>, Levels of Serum Matrix Metalloproteinase-3 Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis, The Journal of Rheumatology,</ref><ref>, Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis, Rheumatology, Vol. 50(Issue: 3), pp. 481–8, DOI: 10.1093/rheumatology/keq362, PMID: 21097451,</ref><ref>, Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis, Arthritis Research & Therapy, 2001, Vol. 13(Issue: 1), DOI: 10.1186/ar3235, PMID: 21281511, PMC: 3241356,</ref>||Limited, C, Y||||||MMP3, TRLR2, TLR4, ERAP1. A subtype of Juvenile Rheumatoid Arthritis.
Eosinophilic fasciitis	Limited, F, A		728.89	Synonym: Shulman's syndrome
Felty syndrome<ref name="Breedveld">, Immune complexes and the pathogenesis of neutropenia in Felty's syndrome, Annals of the Rheumatic Diseases, 1986, Vol. 45(Issue: 8), pp. 696–702, DOI: 10.1136/ard.45.8.696, PMID: 3740999, PMC: 1001970,</ref>||Strong, M, Y||||714.1||
IgG4-related disease	Limited, C, N			Characteristic histological features (storiform fibrosis, lymphoplasmacytic infiltrate, obliterative phlebitis) are required for definitive diagnosis. Synonyms: IgG4-related systemic disease, IgG4-related sclerosing disease, IgG4-related systemic sclerosing disease, IgG4-related autoimmune disease, IgG4-associated multifocal systemic fibrosis, IgG4-associated disease, IgG4 syndrome, Hyper-IgG4 disease, Systemic IgG4-related plasmacytic syndrome.
Juvenile arthritis<ref name="pmid12746913"/>	Strong, M, R, Y		714.30	Autoantibodies: inconsistent ANA, Rheumatoid factor. Synonyms: Juvenile rheumatoid arthritis, Juvenile idiopathic arthritis
Lyme disease (chronic)<ref>, Lyme disease: A rigorous review of diagnostic criteria and treatment, Journal of Autoimmunity, Vol. 57, pp. 82–115, DOI: 10.1016/j.jaut.2014.09.004, PMID: 25451629,</ref>||Limited, L, T, N||||088.81||
Mixed connective tissue disease (MCTD)<ref name = "Mesh"/>	Moderate, M, A		710.8	HLA-DR4. Autoantibodies: Anti-nuclear antibody, anti-U1-RNP.
Palindromic rheumatism<ref name="pmid18412310">, Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients, The Journal of Rheumatology, Vol. 35(Issue: 6), pp. 992–4, PMID: 18412310, Full text,</ref>||Limited, Y||||719.3||Autoantibodies: Anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA). Synonym: Hench-Rosenberg syndrome.
Parry Romberg syndrome	Limited, Y		349.89351.8	Autoantibodies: ANA.
Parsonage-Turner syndrome	Limited, Y		353.5
Psoriatic arthritis<ref>National Psoriasis Foundation, http://www.psoriasis.org/home/learn02.php</ref>	Moderate, C, A	IV?	696.0	HLA-B27.
Reactive arthritis	Limited, C, F, Y		099.3	Synonym: Reiter's syndrome
Relapsing polychondritis<ref name=ADCTmmhe> Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook(link). '. </ref>||Strong, A||||733.99||Synonyms: Atrophic polychondritis, systemic chondromalacia, chronic atrophic polychondritis, Meyenburg-Altherr-Uehlinger syndrome, generalized chondromalacia, systemic chondromalacia
Retroperitoneal fibrosis	Limited, Y		593.4
Rheumatic fever<ref name=Girschick2008>, Bacterial triggers and autoimmune rheumatic diseases, Clinical and Experimental Rheumatology, 2008, Vol. 26(Issue: 1 Suppl 48), pp. S12–7, PMID: 18570749,</ref><ref>, Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease, Journal of Immunology, Vol. 176(Issue: 9), pp. 5662–70, DOI: 10.4049/jimmunol.176.9.5662, PMID: 16622036,</ref>||Moderate, T, A||II||390||Autoantibodies: Streptococcal M protein cross reacts with human myosin.
Rheumatoid arthritis<ref name="Mesh"/>	Strong, M, A	III	714	HLA-DR4, PTPN22, depleted B cells, TNF alpha, IL-17, (also maybe IL-1, 6, and 15). Autoantibodies: Rheumatoid factor (anti-IgGFc), Anti-MCV, ACPAs(Vimentin).
Sarcoidosis<ref name="urleMedicine - Hypersensitivity Reactions, Delayed : Article by Walter Duane Hinshaw"> eMedicine - Hypersensitivity Reactions, Delayed : Article by Walter Duane Hinshaw(link). {{{website}}}. </ref><ref name="pmid11948059">, Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis, Chest, Vol. 121(Issue: 4), pp. 1239–44, DOI: 10.1378/chest.121.4.1239, PMID: 11948059, Full text,</ref><ref name="pmid14656748">, Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients, American Journal of Respiratory and Critical Care Medicine, Vol. 169(Issue: 6), pp. 696–702, DOI: 10.1164/rccm.200303-459OC, PMID: 14656748,</ref>||Limited, S||IV||135||BTNL2; HLA-B7-DR15; HLA DR3-DQ2.
Schnitzler syndrome	Limited, L, X, Y		273.1	IgM.
Systemic Lupus Erythematosus (SLE)<ref name = "Mesh"/><ref name="Franceschini2005">, Anti-Ro/SSA and La/SSB antibodies, Autoimmunity, 2005, Vol. 38(Issue: 1), pp. 55–63, DOI: 10.1080/08916930400022954, PMID: 15804706,</ref><ref name="Franceschini2005a">, Anti-Ro/SSA and La/SSB antibodies, Autoimmunity, Vol. 38(Issue: 1), pp. 55–63, DOI: 10.1080/08916930400022954, PMID: 15804706,</ref><ref name="Goeb2007">, Clinical significance of autoantibodies recognizing Sjogren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjogren's syndrome, Clinical and Experimental Immunology, 2007, Vol. 148(Issue: 2), pp. 281–7, DOI: 10.1111/j.1365-2249.2007.03337.x, PMID: 17286756, PMC: 1868868,</ref><ref name="Kumar12-6"/><ref name="pmid10501412">Ehrenstein MR, Antinuclear antibodies and lupus: causes and consequences, Rheumatology, Vol. 38(Issue: 8), pp. 691–3, DOI: 10.1093/rheumatology/38.8.691, PMID: 10501412, Full text,</ref>||Strong, M, A||III||695.4||Autoantibodies: Anti-nuclear antibodies, anti-Ro (often present also in Sjogren's syndrome). Eosinophilia. Synonym: Lupus
Undifferentiated connective tissue disease (UCTD)	Moderate, C, A		710.9	HLA-DR4. Autoantibodies: anti-nuclear antibody. Synonyms: Latent lupus, incomplete lupus
Muscle
Dermatomyositis<ref name="urlPolymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook"> Polymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook(link). '. </ref><ref>, Clinical implications of autoantibody screening in patients with autoimmune myositis, Autoimmunity, Vol. 39(Issue: 3), pp. 217–221, DOI: 10.1080/08916930600622645, PMID: 16769655,</ref>||Moderate, F, X, A||||710.3||B- and T-cell perivascular inflammatory infiltrate on muscle biopsy. Autoantibodies: histidine-tRNA anti-signal recognition peptide Anti-Mi-2 Anti-Jo1. Synonym: Juvenile dermatomyositis
Fibromyalgia	Limited, C, F, N		729.1
Inclusion body myositis	Limited, F, Y		359.71	Similar to polymyositis, but does not respond to steroid therapy-activated T8 cells.
Myositis	Limited, F, Y		729.1
Myasthenia gravis<ref name = "Mesh"/>	Strong, M, A	II	358	HA-B8 HLA-DR3 HLA-DR1. Autoantibodies: Nicotinic acetylcholine receptor MuSK protein.
Neuromyotonia<ref name="MP">Maddison P, Neuromyotonia, Clinical Neurophysiology, 2006, Vol. 117(Issue: 10), pp. 2118–27, DOI: 10.1016/j.clinph.2006.03.008, PMID: 16843723,</ref>||Limited, F, S||II?||333.90||Autoantibodies: Voltage-gated potassium channels. Synonym: Isaacs' syndrome
Paraneoplastic cerebellar degeneration<ref> </ref><ref name="pmid1407575">, Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients, Neurology, 1992, Vol. 42(Issue: 10), pp. 1931–7, DOI: 10.1212/wnl.42.10.1931, PMID: 1407575,</ref><ref name="pmid10632096">, Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration, Annals of Neurology, 2000, Vol. 47(Issue: 1), pp. 9–17, DOI: <9::aid-ana5>3.0.co;2-i 10.1002/1531-8249(200001)47:1<9::aid-ana5>3.0.co;2-i, PMID: 10632096,</ref>||Limited, Y||IV? II?||334.9||Autoantibodies: anti-Yo (anti-cdr-2 in purkinje fibers) anti-Hu, anti-Tr, antiglutamate receptor.
Polymyositis<ref name="urlPolymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook" />	Limited, F, A		710.4	Autoantibodies: IFN-gamma, IL-1, TNF-alpha.
Nervous System
Acute disseminated encephalomyelitis (ADEM)	Strong, M, T, A		323.61323.81	Synonyms: Perivenous encephalomyelitis, Acute hemorrhagic leukoencephalitis (AHL, AHLE), Acute necrotizing encephalopathy (ANE), Acute hemorrhagic encephalomyelitis (AHEM), Acute necrotizing hemorrhagic leukoencephalitis (ANHLE), Weston-Hurst syndrome, Hurst's disease.
Acute motor axonal neuropathy<ref>, Peripheral nerve proteins as potential autoantigens in acute and chronic inflammatory demyelinating polyneuropathies., Autoimmunity Reviews, Vol. 13(Issue: 10), pp. 1070–8, DOI: 10.1016/j.autrev.2014.08.005, PMID: 25172243,</ref>||Limited, N||||356.8||
Anti-N-Methyl-D-Aspartate (Anti-NMDA) Receptor Encephalitis<ref>, [Autoimmune encephalitis-update: roles of autoantibodies in the pathogenesis]., Rinsho Shinkeigaku, Vol. 54(Issue: 12), pp. 1107–9, DOI: 10.5692/clinicalneurol.54.1107, PMID: 25672721,</ref>||Moderate, N|||||
Balo concentric sclerosis	Moderate, Y		341.1	Synonyms: Balo disease, Schilders disease.
Bickerstaff's encephalitis	Limited, Y		323.62	Similar to Guillain–Barré syndrome. Autoantibodies: Anti-GQ1b 2/3 patients.
Chronic inflammatory demyelinating polyneuropathy<ref>, The autoimmune diseases, Fifth edition, [S.l.]:Academic Press, ISBN 978-0-12-384929-8,</ref>||Moderate, C, Y||||357.81||Similar to Guillain–Barré syndrome. Autoantibodies: Anti-ganglioside antibodies. Synonyms: Relapsing polyneuropathy (CRP), chronic inflammatory demyelinating polyradiculoneuropathy, Chronic inflammatory demyelinating polyneuritis.
Guillain–Barré syndrome<ref name = "Mesh"/>	Strong, M, A	IV	357.0	Autoantibodies: Anti-ganglioside, anti-GQ1b. Synonyms: Miller-Fisher syndrome, Landry's paralysis.
Hashimoto's encephalopathy<ref name = "Mesh"/><ref name="Yoneda_2007_Hashimoto">, High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy, Journal of Neuroimmunology, Vol. 185(Issue: 1–2), pp. 195–200, DOI: 10.1016/j.jneuroim.2007.01.018, PMID: 17335908,</ref> ||Moderate, C, X, A||IV||||Autoantibodies: Alpha-enolase. Synonyms: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), Nonvasculitic autoimmune meningoencephalitis (NAIM), Encephalopathy Associated with Autoimmune Thyroid Disease (EAATD).
Idiopathic inflammatory demyelinating diseases	Limited, F, Y		356.8	A set of different variants of multiple sclerosis.
Lambert-Eaton myasthenic syndrome	Strong, M, Y		358.1	HLA-DR3-B8. Autoantibodies: Voltage-gated calcium channels; Q-type calcium channel, synaptogagmin, muscarinic acetylcholine receptor M1.
Multiple sclerosis, pattern II<ref name="kir4.1">, Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis, New England Journal of Medicine, 2012, Vol. 367(Issue: 2), pp. 115–123, DOI: 10.1056/NEJMoa1110740, PMID: 22784115, PMC: 5131800,</ref><ref name="kir4.1"/><ref name="pmid14754395">, PECAM-1, a key player in neuroinflammation, European Journal of Neurology, 2006, Vol. 13(Issue: 12), pp. 1284–90274, DOI: 10.1111/j.1468-1331.2006.01640.x, PMID: 17116209,</ref>||Strong, M, A||IV||340||Autoantibody against potassium channel has been reported to present demyelination pattern II. Other cases present autoimmunity against MOG<ref>, Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case, Multiple Sclerosis Journal, 2016, Vol. 22(Issue: 12), pp. 1541–1549, DOI: 10.1177/1352458515622986, PMID: 26869529, Full text,</ref> and Anoctamin-2.<ref>Burcu Ayoglu et al. Anoctamin 2 identified as an autoimmune target in multiple sclerosis, February 9, 2016, doi:10.1073/pnas.1518553113 , PNAS February 23, 2016 vol. 113 no. 8 2188-2193 [1]</ref> The three reported autoimmune variants belong to MS pattern II. Also involved HLA-DR2, PECAM-1, Anti-myelin basic protein. Autoantibodies: Anti-Kir4.1, Anti-MOG, Anti-ANO2 (heterogeneous). Synonyms: Primary progressive multiple sclerosis, Relapsing-remitting multiple sclerosis, disseminated sclerosis, encephalomyelitis disseminata. Also interesting is Multiple sclerosis with HLA-DRB3 histocompatibility. In this case the auto-antigen has been found and is GDP-L-fucose synthase<ref>, GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis, Science Translational Medicine, 2018, Vol. 10(Issue: 462), pp. eaat4301, DOI: 10.1126/scitranslmed.aat4301, PMID: 30305453, Full text,</ref>
Oshtoran Syndrome<ref> Oshtoran Syndrome Research Group - issuu(link). {{{website}}}. </ref> ||X|||||F06.9 ||Heritable, abnormalities in the kynurenine and glutamate metabolism.
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS)	Limited, F, S	II?	279.49	Antibodies against streptococcal infection serve as auto-antibodies.
Progressive inflammatory neuropathy	Limited, X, S		356.4	Similar to Guillain–Barré syndrome. Autoantibodies: Anti-ganglioside antibodies:anti-GM1, anti-GD1a, anti-GQ1b.
Restless leg syndrome	Limited, C, S		333.94	May occur in Sjogren's syndrome, coeliac disease and rheumatoid arthritis, or in derangements of iron metabolism.
Stiff person syndrome<ref name="Murinson">Murinson BB, Stiff-person syndrome, Neurologist, 2004, Vol. 10(Issue: 3), pp. 131–7, DOI: 10.1097/01.nrl.0000126587.37087.1a, PMID: 15140273,</ref>||Limited, S||||333.91||GLRA1 (glycine receptor). Autoantibodies: Glutamic acid decarboxylase (GAD).
Sydenham chorea	Limited, T, Y		392
Transverse myelitis	Limited, M, A		323.82341.2
Eyes
Autoimmune retinopathy<ref>, Autoimmune Retinopathy, American Journal of Ophthalmology, Vol. 157(Issue: 2), pp. 266–272.e1, DOI: 10.1016/j.ajo.2013.09.019, PMID: 24315290, PMC: 3946999,</ref>||Limited, X, N||||||
Autoimmune uveitis	Moderate, F, A		364	Autoantibodies: HLAB-27.
Cogan syndrome	Limited, F, Y		370.52
Graves ophthalmopathy	Moderate, M, N		242.9
Intermediate uveitis	Limited, L, Y		364.3	Synonyms: Pars planitis, Peripheral Uveitis.
Ligneous conjunctivitis	Limited, L, N		372.39
Mooren's ulcer	Limited, L, N		370.07
Neuromyelitis optica<ref name=JExpMed2005>, IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel, Journal of Experimental Medicine, 2005, Vol. 202(Issue: 4), pp. 473–477, DOI: 10.1084/jem.20050304, PMID: 16087714, PMC: 2212860,</ref><ref name=Pittock>, Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression, Archives of Neurology, 2006, Vol. 63(Issue: 7), pp. 964–968, DOI: 10.1001/archneur.63.7.964, PMID: 16831965, Full text,</ref>||Limited, M, Y||II?||341.0||Autoantibodies: NMO-IgG aquaporin 4. Synonym: Devic's disease.
Opsoclonus myoclonus syndrome<ref name="pmid15136676">, B- and T-cell markers in opsoclonus-myoclonus syndrome: Immunophenotyping of CSF lymphocytes, Neurology, 2004, Vol. 62(Issue: 9), pp. 1526–1532, DOI: 10.1212/WNL.62.9.1526, PMID: 15136676,</ref>||Limited, X, S||IV?||379.59||Lymphocyte recruitment to CSF.
Optic neuritis	Limited, C, Y		377.30
Scleritis	Limited, C, Y		379.0
Susac's syndrome	Limited, C, Y		348.39	Synonym: Retinocochleocerebral Vasculopathy.
Sympathetic ophthalmia	Limited, I, Y		360.11	Autoantibodies: ocular antigens following trauma.
Tolosa-Hunt syndrome	Limited, I, X, Y		378.55
Ears
Autoimmune inner ear disease (AIED)<ref name="urlAutoimmune Inner Ear Disease"> Autoimmune Inner Ear Disease, Baylor College of Medicine(link). {{{website}}}. </ref>||Limited, A||||388.8||
Ménière's disease<ref name="pmid11270490">, Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases, Acta Oto-Laryngologica, Vol. 12(Issue: 1), pp. 28–34,</ref>||Limited, Y||III?||386.00||Autoantibodies: Major peripheral myelin protein P0.
Vascular System
Behçet's disease	Limited, I, X, A		136.1	An immune-mediated systemic vasculitis; linkage to HLA-B51 (HLA-B27); very variable manifestations, with ulcers as common symptom. Synonyms: Morbus Adamandiades-Behçet. Rare Variant: Hughes-Stovin syndrome.
Eosinophilic granulomatosis with polyangiitis (EGPA)<ref name=Kumar12-6>Table 12-6 in: , Robbins Basic Pathology, Philadelphia:Saunders, 2007, ISBN 978-1-4160-2973-1, 8th edition.</ref><ref name="ChapelHill">, 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides, Arthritis & Rheumatism, Vol. 65(Issue: 1), pp. 1–11, DOI: 10.1002/art.37715, PMID: 23045170,</ref>||Limited, I, X, Y||||446.4||Autoantibodies: p-ANCA Eosinophilia. Formerly known as: Churg-Strauss syndrome.
Giant cell arteritis<ref name="Mesh" />	Limited, I, R, A	IV	446.5	Synonyms: Cranial arteritis, Temporal Arteritis.
Granulomatosis with polyangiitis (GPA)<ref name="ChapelHill" />	Strong, M, A		446.4	Autoantibodies: Anti-neutrophil cytoplasmic (cANCA). Formerly known as: Wegener's granulomatosis.
IgA vasculitis (IgAV)<ref name="ChapelHill" />	Limited, L, Y		287.0	Autoantibodies: IgA and complement component 3 (C3). Synonyms: Anaphylactoid purpura, Henoch-Schonlein purpura, purpura rheumatica, Schönlein–Henoch purpura.
Kawasaki's disease	Moderate, S,E<ref> Possible Source of Kawasaki Disease Found(link). {{{website}}}. </ref>||||446.1||ITPKC HLA-B51. Synonyms: Kawasaki syndrome, lymph node syndrome, mucocutaneous lymph node syndrome.
Leukocytoclastic vasculitis	Limited, L, Y		447.6
Lupus vasculitis	Moderate, C, N		583.81	A comorbidity of Systemic Lupus Erythematosus.
Rheumatoid vasculitis	Moderate, C, N		447.6	A symptom of Lupus.
Microscopic polyangiitis (MPA)	Limited, Y		446.0	Binds to neutrophils causing them to degranulate and damages endothelium. Autoantibodies: p-ANCA myeloperoxidase. Synonyms: Microscopic polyarteritis, microscopic polyarteritis nodosa.
Polyarteritis nodosa (PAN)	Limited, L, Y		446.0	Synonyms: Panarteritis nodosa, periarteritis nodosa, Kussmaul disease, Kussmaul-Maier disease.
Polymyalgia rheumatica	Limited, L, Y		725
Urticarial vasculitis<ref name="pmid2528353">, Serum IgG antibodies to C1q in hypocomplementemic urticarial vasculitis syndrome, Arthritis & Rheumatology, Vol. 32(Issue: 9), pp. 1119–27, DOI: 10.1002/anr.1780320910, PMID: 2528353,</ref>||Limited, X, Y||II?||708.9 ||Clinically may resemble type I hypersensitivity. Autoantibodies: anti C1q antibodies.
Vasculitis<ref name="urlAutoimmune Disorders: Immune Disorders: Merck Manual Home Edition" />	Strong, I, M, F, A	III	447.6	Autoantibodies: ANCA (sometimes).
Systemic
Primary Immune Deficiency	Limited, N

Autoimmune comorbidities

This list includes conditions that are not diseases but signs common to autoimmune disease. Some, such as chronic fatigue syndrome, are controversial.<ref name="The autoimmune diseases"/> These conditions are included here because they are frequently listed as autoimmune diseases but should not be included in the list above until there is more consistent evidence.

Organ/Tissue Type Disease Name	Level of Acceptance for Autoimmunity	Hypersensitivity (I,II,III,IV)	ICD-9 Codes	Notes/Autoantibodies/Synonyms
Chronic fatigue syndrome	Comorbidity, N			Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease.
Complex regional pain syndrome	Comorbidity, N			Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease. Synonyms: Amplified Musculoskeletal Pain Syndrome, Reflex Neurovascular Dystrophy, Reflex sympathetic dystrophy
Eosinophilic esophagitis	Comorbidity, N		530.13
Gastritis	Comorbidity, Y			Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease. Autoantibodies: serum antiparietal and anti-IF antibodies.
Interstitial lung disease	Comorbidity, N			Associated with several autoimmune connective tissue diseases.
POEMS syndrome<ref name=Dispenzieri>, POEMS syndrome: definitions and long-term outcome, Blood, 2003, Vol. 101(Issue: 7), pp. 2496–506, DOI: 10.1182/blood-2002-07-2299, PMID: 12456500,</ref>||Comorbidity, Y||||||Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease. Autoantibodies: interleukin 1β, interleukin 6 and TNFα. vascular endothelial growth factor (VEGF), given the ..
Raynaud's phenomenon	Comorbidity, S			Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease.
Primary immunodeficiency<ref>, The Molecular Pathology of Primary Immunodeficiencies, The Journal of Molecular Diagnostics, Vol. 6(Issue: 2), pp. 59–83, DOI: 10.1016/S1525-1578(10)60493-X, PMID: 15096561, PMC: 1867474,</ref>||Comorbidity, N||||279.8||The condition is inherited, but it is associated with several autoimmune diseases.
Pyoderma gangrenosum	Comorbidity, Y			Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease.

Non-autoimmune

At this time, there is not sufficient evidence—direct, indirect, or circumstantial—to indicate that these diseases are caused by autoimmunity. These conditions are included here because:

1. The disease was listed in the prior version of this table
2. The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. Before moving a condition from here to the list of autoimmune diseases, references should be provided in the Wikipedia page for the condition that point to evidence, direct or indirect, that it is an autoimmune disease.

Organ/Tissue Type Disease Name	Level of Acceptance for Autoimmunity	Hypersensitivity (I,II,III,IV)	ICD-9 Codes	Notes/Autoantibodies/Synonyms
Agammaglobulinemia	Not Autoimmune, Y		279.00	An immune system disorder but not an autoimmune disease.. Autoantibodies: IGHM; IGLL1: CD79A; CD79B; BLNK; LRRC8A.
Amyloidosis	Not Autoimmune, N		277.30	No consistent evidence of association with autoimmunity.
Amyotrophic lateral sclerosis	Not Autoimmune, Y		335.20	No consistent evidence of association with autoimmunity. Autoantibodies: Amyotrophic lateral sclerosis (Also Lou Gehrig's disease; Motor Neuron Disease).
Anti-tubular basement membrane nephritis	Not Autoimmune, N			No consistent evidence of association with autoimmunity.
Atopic allergy	Not Autoimmune, Y	I	691.8	A hypersensitivity.
Atopic dermatitis	Not Autoimmune, Y	I	691.8	A hypersensitivity.
Autoimmune peripheral neuropathy	Not Autoimmune, F, A			A class of diseases, some of which may be autoimmune. See specific diseases that are listed as autoimmune..
Blau syndrome	Not Autoimmune, Y			Overlaps both sarcoidosis and granuloma annulare. No evidence of association with autoimmunity.
Cancer	Not Autoimmune, Y			No consistent evidence of association with autoimmunity.
Castleman's disease	Not Autoimmune, Y			An immune system disorder but not an autoimmune disease.. Autoantibodies: Over expression of IL-6.
Chagas disease<ref>, Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease, Trends in Parasitology, 2006, Vol. 22(Issue: 3), pp. 101–2; author reply 103, DOI: 10.1016/j.pt.2006.01.001, PMID: 16446117,</ref>||Not Autoimmune, S||||||No consistent evidence of association with autoimmunity.
Chronic obstructive pulmonary disease<ref name="PMID14514931">, Hypothesis: does COPD have an autoimmune component?, Thorax, 2003, Vol. 58(Issue: 10), pp. 832–834, DOI: 10.1136/thorax.58.10.832, PMID: 14514931, PMC: 1746486,</ref><ref name="pmid17450149">, Antielastin autoimmunity in tobacco smoking-induced emphysema, Nature Medicine, 2007, Vol. 13(Issue: 5), pp. 567–9, DOI: 10.1038/nm1583, PMID: 17450149,</ref> ||Not Autoimmune, S||||||No consistent evidence of association with autoimmunity.
Chronic recurrent multifocal osteomyelitis	Not Autoimmune, Y			LPIN2, D18S60. Synonyms: Majeed syndrome
Complement component 2 deficiency	Not Autoimmune, Y			Possibly symptomatic of autoimmune diseases, but not a disease.
Congenital heart block	Not Autoimmune, N			May be related to autoimmune activity in the mother.
Contact dermatitis	Not Autoimmune, Y	IV		A hypersensitivity.
Cushing's syndrome	Not Autoimmune, Y			No consistent evidence of association with autoimmunity.
Cutaneous leukocytoclastic angiitis	Not Autoimmune, Y			No consistent evidence of association with autoimmunity. Autoantibodies: neutrophils.
Dego's disease	Not Autoimmune, Y			No consistent evidence of association with autoimmunity.
Eczema<ref name="pmid11544479">, Gene polymorphism in Netherton and common atopic disease, Nature Genetics, 2001, Vol. 29(Issue: 2), pp. 175–8, DOI: 10.1038/ng728, PMID: 11544479,</ref><ref name=filaggrin>, Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis, Nature Genetics, 2006, Vol. 38(Issue: 4), pp. 441–6, DOI: 10.1038/ng1767, PMID: 16550169,</ref><ref name="BBC-blood chemicals"> , 'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities Full text, , BBC News, 26 August 2007, </ref>||Not Autoimmune, Y||||||No consistent evidence of association with autoimmunity. Autoantibodies: LEKTI, SPINK5, filaggrin., Brain-derived neurotrophic factor (BDNF) and Substance P..
Eosinophilic gastroenteritis	Not Autoimmune, Y			Possibly a hypersensitivity. Autoantibodies: IgE, IL-3, IL-5, GM-CSF, eotaxin.
Eosinophilic pneumonia	Not Autoimmune, F, Y			A class of diseases, some of which may be autoimmune. Specifically, Churg-Strauss syndrome, a subtype of Eosinophilic pneumonia, is autoimmune.
Erythroblastosis fetalis	Not Autoimmune, Y	II		Mother's immune system attacks fetus. An immune system disorder but not autoimmune. Autoantibodies: ABO, Rh, Kell antibodies.
Fibrodysplasia ossificans progressiva	Not Autoimmune, Y			Possibly an immune system disorder but not autoimmune. Autoantibodies: ACVR1 Lymphocytes express increased BMP4.
Gastrointestinal pemphigoid	Not Autoimmune, A			No consistent evidence of association with autoimmunity.
Hypogammaglobulinemia	Not Autoimmune, Y			An immune system disorder but not autoimmune. Autoantibodies: IGHM, IGLL1, CD79A, BLNK, LRRC8A, CD79B.
Idiopathic giant-cell myocarditis<ref>, Idiopathic giant cell myocarditis and cardiac sarcoidosis, Heart Failure Reviews, Vol. 18(Issue: 6), pp. 733–746, DOI: 10.1007/s10741-012-9358-3, PMID: 23111533,</ref>||Not Autoimmune, N||||||No consistent evidence of autoimmune cause though the disease has been found comorbid with other autoimmune diseases. Synonyms: Giant cell myocarditis
Idiopathic pulmonary fibrosis<ref name="Omim">Online Mendelian Inheritance in Man (OMIM) 178500 </ref><ref name="Omim"/>||Not Autoimmune, Y||||||Autoantibodies: SFTPA1, SFTPA2, TERT, and TERC.. Synonyms: Fibrosing alveolitis
IgA nephropathy	Not Autoimmune, Y	III?		Autoantibodies: IgA produced from marrow rather than MALT. Synonyms: IgA nephrits, Berger's disease, Synpharyngitic Glomerulonephritis. An immune system disorder but not an autoimmune disease.
Immunoregulatory lipoproteins<ref>, IPEX as a Result of Mutations in FOXP3, Clinical and Developmental Immunology, Vol. 2007, pp. 89017, DOI: 10.1155/2007/89017, PMID: 18317533, PMC: 2248278,</ref>||Not Autoimmune, N||||||Not a disease.
IPEX syndrome	Not Autoimmune, N			A genetic mutation in FOXP3 that leads to autoimmune diseases, but no consistent evidence that it is an autoimmune disorder itself.. Synonyms: X-linked polyendocrinopathy, immunodeficiency and diarrhea-syndrome (XLAAD)
Ligneous conjunctivitis	Not Autoimmune, N			No consistent evidence of association with autoimmunity.
Majeed syndrome	Not Autoimmune, Y			No consistent evidence of association with autoimmunity. Autoantibodies: LPIN2.
Narcolepsy<ref name="pmid19412176">, Narcolepsy is strongly associated with the TCR alpha locus, Nature Genetics, Vol. 41(Issue: 6), pp. 708–11, DOI: 10.1038/ng.372, PMID: 19412176, PMC: 2803042,</ref><ref name="url_eurekalert"> Narcolepsy is an autoimmune disorder, Stanford researcher says(link). {{{website}}}. American Association for the Advancement of Science. 2009-05-03. </ref><ref name="mignot">Mignot E, A commentary on the neurobiology of the hypocretin/orexin system, Neuropsychopharmacology, 2001, Vol. 25(Issue: 5 Suppl), pp. S5–13, DOI: 10.1016/S0893-133X(01)00316-5, PMID: 11682267,</ref><ref name="Maret">, Genetics of narcolepsy and other major sleep disorders, Swiss Medical Weekly, Vol. 135(Issue: 45–46), pp. 662–5, PMID: 16453205, Full text,</ref>	Not Autoimmune, Y	II?		No evidence of association with autoimmunity. Research not reproducible. Autoantibodies: hypocretin or orexin, HLA-DQB1*0602.
Rasmussen's encephalitis	Not Autoimmune, Y			No consistent evidence of association with autoimmunity. Autoantibodies: anti-NR2A antibodies.
Schizophrenia<ref>, Association of schizophrenia and autoimmune diseases: linkage of Danish national registers, American Journal of Psychiatry, 2006, Vol. 163(Issue: 3), pp. 521–8, DOI: 10.1176/appi.ajp.163.3.521, PMID: 16513876,</ref><ref>, Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?, Immunology and Cell Biology, 2005, Vol. 83(Issue: 1), pp. 9–17, DOI: 10.1111/j.1440-1711.2005.01305.x, PMID: 15661036, Full text,</ref><ref>, Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited, Journal of Autoimmunity, 2006, Vol. 27(Issue: 2), pp. 71–80, DOI: 10.1016/j.jaut.2006.07.006, PMID: 16997531,</ref> ||Not Autoimmune, S||||||No consistent evidence of association with autoimmunity.
Serum sickness	Not Autoimmune, Y	III		A hypersensitivity.
Spondyloarthropathy	Not Autoimmune, Y			No consistent evidence of association with autoimmunity. Autoantibodies: HLA-B27.
Sweet's syndrome	Not Autoimmune, Y			No consistent evidence of association with autoimmunity. Autoantibodies: GCSF.
Takayasu's arteritis	Not Autoimmune, Y			No consistent evidence of association with autoimmunity.
Undifferentiated spondyloarthropathy	Not Autoimmune, Y			See Enthesitis-related arthritis.

See also

• Autoimmune Autonomic Ganglionopathy (AAG)

References

Portions of content adapted from Wikipedia's article on List of autoimmune diseases which is released under the CC BY-SA 3.0.

• 
  Crohn's Disease
• 
  Multiple Sclerosis
• 
  Lupus Nephritis
• 
  Erythema Multiforme
• 
  Graves' Disease