IgA nephropathy

IgA Nephropathy

IgA nephropathy, pronounced as /ˌaɪdʒiːˈeɪ nɪˈfrɒpəθi/, also known as Berger's disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) lodges in your kidneys. This results in local inflammation that, over time, may hamper your kidneys' ability to filter wastes from your blood.

Etymology

The term "IgA nephropathy" is derived from the name of the antibody involved (IgA or Immunoglobulin A) and the Greek word "nephros" meaning kidney, and "pathy" meaning disease. The disease is also named after Dr. Jean Berger who first described the condition in 1968.

Symptoms

Early stages of IgA nephropathy may show no noticeable signs or symptoms. However, common symptoms include hematuria (blood in urine), proteinuria (protein in urine), and high blood pressure.

Causes

IgA nephropathy is caused by the deposition of the IgA antibody in the kidneys. However, it is not clear why the body forms these deposits. It is believed to be a combination of genetic and environmental factors.

Diagnosis

Diagnosis of IgA nephropathy usually requires a kidney biopsy, where a small piece of kidney tissue is removed for examination under a microscope.

Treatment

Treatment for IgA nephropathy aims to prevent or slow the progression of the disease. This may include medications to control high blood pressure, reduce proteinuria, and reduce cholesterol levels. In severe cases, dialysis or a kidney transplant may be necessary.

Related Terms

• Chronic kidney disease
• Glomerulonephritis
• End-stage renal disease
• Kidney failure

External links

• Medical encyclopedia article on IgA nephropathy
• Wikipedia's article - IgA nephropathy

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